U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    etr-1 RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173401, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    etr-1
    Official Full Name
    RRM domain-containing protein
    Primary source
    WormBase:WBGene00001340
    Locus tag
    CELE_T01D1.2
    See related
    AllianceGenome:WB:WBGene00001340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Involved in determination of adult lifespan. Located in nucleus. Is expressed in body wall musculature; copulatory spicule; germ line; muscle cell; and somatic gonad. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 97. Orthologous to several human genes including CELF1 (CUGBP Elav-like family member 1). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See etr-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    14
    Sequence:
    Chromosome: II; NC_003280.10 (162423..170631)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine receptor class gamma Neighboring gene BPTI/Kunitz inhibitor domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Caenorhabditis elegans ETR-1/CELF has broad effects on the muscle cell transcriptome, including genes that regulate translation and neuroblast migration. Ochs ME, et al. BMC Genomics, 2022 Jan 6. PMID 34986795, Free PMC Article
    2. The Predicted RNA-Binding Protein ETR-1/CELF1 Acts in Muscles To Regulate Neuroblast Migration in Caenorhabditis elegans. Ochs ME, et al. G3 (Bethesda), 2020 Jul 7. PMID 32398235, Free PMC Article
    3. ETR-1, a homologue of a protein linked to myotonic dystrophy, is essential for muscle development in Caenorhabditis elegans. Milne CA, et al. Curr Biol, 1999 Nov 4. PMID 10556089
    4. Novel functions for the RNA-binding protein ETR-1 in Caenorhabditis elegans reproduction and engulfment of germline apoptotic cell corpses. Boateng R, et al. Dev Biol, 2017 Sep 1. PMID 28648844, Free PMC Article
    5. Growth-dependent effect of muscleblind knockdown on Caenorhabditis elegans. Wang LC, et al. Biochem Biophys Res Commun, 2008 Feb 15. PMID 18082131

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this data identifies a novel role for ETR-1 in hermaphrodite gametogenesis and in the process of engulfment of germline apoptotic cell corpses.
      Title: Novel functions for the RNA-binding protein ETR-1 in Caenorhabditis elegans reproduction and engulfment of germline apoptotic cell corpses.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    RRM domain-containing protein
    NP_001367867.1
    • Confirmed by transcript evidence
    NP_001367869.1
    • Confirmed by transcript evidence
    NP_001367870.1
    • Confirmed by transcript evidence
    NP_001367871.1
    • Confirmed by transcript evidence
    NP_001368521.1
    • Confirmed by transcript evidence
    NP_001368522.1
    • Confirmed by transcript evidence
    NP_001368523.1
    • Confirmed by transcript evidence
    NP_001368524.1
    • Confirmed by transcript evidence
    NP_001368525.1
    • Confirmed by transcript evidence
    NP_001368526.1
    • Confirmed by transcript evidence
    NP_001368527.1
    • Confirmed by transcript evidence
    NP_001368528.1
    • Confirmed by transcript evidence
    NP_001368529.1
    • Confirmed by transcript evidence
    NP_001368530.1
    • Confirmed by transcript evidence
    NP_001368531.1
    • Confirmed by transcript evidence
    NP_001368532.1
    • Confirmed by transcript evidence
    NP_001368533.1
    • Confirmed by transcript evidence
    NP_001370740.1
    • Confirmed by transcript evidence
    NP_001379970.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      162423..170631
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381293.1 → NP_001367870.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYS1
      Conserved Domains (4) summary
      TIGR01628
      Location:57 → 580
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12362
      Location:503 → 575
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
      cd12631
      Location:54 → 135
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12636
      Location:141 → 221
      RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

    2. NM_001381292.3 → NP_001367871.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYS0
      Conserved Domains (4) summary
      TIGR01628
      Location:57 → 582
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12362
      Location:505 → 577
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
      cd12631
      Location:54 → 135
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12636
      Location:141 → 221
      RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

    3. NM_001392986.1 → NP_001379970.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7KQE9
      Conserved Domains (3) summary
      cd12362
      Location:430 → 502
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
      cd12631
      Location:54 → 135
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12636
      Location:141 → 221
      RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

    4. NM_001381290.3 → NP_001367867.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF03
      Conserved Domains (3) summary
      cd12362
      Location:501 → 573
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
      cd12631
      Location:54 → 135
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12636
      Location:141 → 221
      RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

    5. NM_001381291.1 → NP_001368521.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUP0
      Conserved Domains (4) summary
      TIGR01628
      Location:57 → 583
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12362
      Location:506 → 578
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
      cd12631
      Location:54 → 135
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cd12636
      Location:141 → 221
      RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

    6. NM_001383771.1 → NP_001370740.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYS3
      Conserved Domains (4) summary
      TIGR01628
      Location:57 → 529
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12362
      Location:452 → 524
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
      cd12631
      Location:54 → 135
      RRM1_CELF1_2_Bruno; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-1, CELF-2, Drosophila melanogaster Bruno protein and similar proteins
      cl17169
      Location:141 → 209
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. NM_001381296.1 → NP_001368522.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AX05
      Conserved Domains (3) summary
      TIGR01661
      Location:285 → 458
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12362
      Location:381 → 453
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
      cd12636
      Location:17 → 97
      RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

    8. NM_001381297.1 → NP_001368523.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARP1
      Conserved Domains (3) summary
      TIGR01661
      Location:285 → 456
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12362
      Location:379 → 451
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
      cd12636
      Location:17 → 97
      RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

    9. NM_001381298.1 → NP_001368524.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AU13
      Conserved Domains (2) summary
      cd12362
      Location:306 → 378
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
      cd12636
      Location:17 → 97
      RRM2_Bruno_like; RNA recognition motif 2 (RRM2) found in Drosophila melanogaster Bruno protein and similar proteins

    10. NM_001381299.1 → NP_001368525.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AR37
      Conserved Domains (3) summary
      TIGR01661
      Location:243 → 416
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12362
      Location:339 → 411
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
      cl17169
      Location:39 → 55
      RRM_SF; RNA recognition motif (RRM) superfamily

    11. NM_001381300.1 → NP_001368526.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUP5
      Conserved Domains (3) summary
      TIGR01661
      Location:243 → 414
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12362
      Location:337 → 409
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
      cl17169
      Location:39 → 55
      RRM_SF; RNA recognition motif (RRM) superfamily

    12. NM_001381301.1 → NP_001368527.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AX10
      Conserved Domains (2) summary
      cd12362
      Location:264 → 336
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins
      cl17169
      Location:39 → 55
      RRM_SF; RNA recognition motif (RRM) superfamily

    13. NM_001381302.1 → NP_001367869.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYR9
      Conserved Domains (1) summary
      cd12362
      Location:269 → 341
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

    14. NM_001381303.1 → NP_001368528.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARP5
      Conserved Domains (2) summary
      TIGR01661
      Location:177 → 350
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12362
      Location:273 → 345
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

    15. NM_001381304.1 → NP_001368529.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AU17
      Conserved Domains (2) summary
      TIGR01661
      Location:177 → 348
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12362
      Location:271 → 343
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

    16. NM_001381305.1 → NP_001368530.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AR42
      Conserved Domains (1) summary
      cd12362
      Location:198 → 270
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

    17. NM_001381306.1 → NP_001368531.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUQ1
      Conserved Domains (2) summary
      TIGR01661
      Location:101 → 274
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12362
      Location:197 → 269
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

    18. NM_001381307.1 → NP_001368532.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AX15
      Conserved Domains (2) summary
      TIGR01661
      Location:101 → 272
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12362
      Location:195 → 267
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

    19. NM_001381308.1 → NP_001368533.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARQ0
      Conserved Domains (1) summary
      cd12362
      Location:122 → 194
      RRM3_CELF1-6; RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins

    RNA

    1. NR_132573.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools