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    mec-8 RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172771, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mec-8
    Official Full Name
    RRM domain-containing protein
    Primary source
    WormBase:WBGene00003172
    Locus tag
    CELE_F46A9.6
    See related
    AllianceGenome:WB:WBGene00003172
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Involved in several processes, including hemidesmosome assembly; mechanosensory behavior; and nematode larval development. Located in nucleus. Is expressed in several structures, including head muscle; hypodermis; intestine; nervous system; and vulva. Orthologous to human RBPMS (RNA binding protein, mRNA processing factor) and RBPMS2 (RNA binding protein, mRNA processing factor 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See mec-8 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (9441010..9444227, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene PRKC apoptosis WT1 regulator protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MEC-8 regulates alternative splicing of unc-52 transcripts in C. elegans hypodermal cells. Spike CA, et al. Development, 2002 Nov. PMID 12397108
    2. Conditional gene expression and RNAi using MEC-8-dependent splicing in C. elegans. Calixto A, et al. Nat Methods, 2010 May. PMID 20364149, Free PMC Article
    3. The mec-8 gene of C. elegans encodes a protein with two RNA recognition motifs and regulates alternative splicing of unc-52 transcripts. Lundquist EA, et al. Development, 1996 May. PMID 8625846
    4. Conserved binding of GCAC motifs by MEC-8, couch potato, and the RBPMS protein family. Soufari H, et al. RNA, 2017 Mar. PMID 28003515, Free PMC Article
    5. Intronic alternative splicing regulators identified by comparative genomics in nematodes. Kabat JL, et al. PLoS Comput Biol, 2006 Jul 14. PMID 16839192, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here we combine RNA-seq with in vitro binding assays to study how 4 different C. elegans SFs, ASD-1, FOX-1, MEC-8, and EXC-7, regulate splicing. The 4 SFs chosen all have well-characterised biology and well-studied loss-of-function genetic alleles, and all contain RRM domains
      Title: The combinatorial control of alternative splicing in C. elegans.
    2. Conserved binding of GCAC motifs by MEC-8, couch potato, and the RBPMS protein family has been reported.
      Title: Conserved binding of GCAC motifs by MEC-8, couch potato, and the RBPMS protein family.
    3. Inclusion of mec-2 intron 9 is sufficient to convey mec-8-dependent regulation on other genes and, in mec-8(u218ts) mutants, resulted in their temperature-dependent expression
      Title: Conditional gene expression and RNAi using MEC-8-dependent splicing in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hemidesmosome assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle organ morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in muscle organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RRM domain-containing protein
    NP_492508.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9441010..9444227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060107.7 → NP_492508.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492508.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECJ4, Q22039
      Conserved Domains (3) summary
      COG0724
      Location:214 → 306
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12245
      Location:226 → 304
      RRM_scw1_like; RNA recognition motif in yeast cell wall integrity protein scw1 and similar proteins
      cl17169
      Location:30 → 112
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version

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