arl-3 ADP-ribosylation factor-like protein 3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: arl-3
Official Full Name: ADP-ribosylation factor-like protein 3
Primary source: WormBase:WBGene00000188
Locus tag: CELE_F19H8.3
See related: AllianceGenome:WB:WBGene00000188
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTP binding activity. Predicted to be involved in cilium assembly. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm and microtubule cytoskeleton. Is expressed in head neurons and tail neurons. Human ortholog(s) of this gene implicated in Joubert syndrome and retinitis pigmentosa 83. Orthologous to human ARL3 (ADP ribosylation factor like GTPase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See arl-3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 2

Sequence:: Chromosome: II; NC_003280.10 (14606472..14608342)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors demonstrate that ARL-3 is a unique small GTPase with unusual high intrinsic GDP release but low intrinsic GTP binding rate. Importantly, ARL-13 acts as a nucleotide exchange factor (GEF) of ARL-3, while UNC-119 can stabilize the GTP binding of ARL-3. We further show that excess inactivated ARL-3 compromises ciliogenesis.
Title: GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119.
Data suggest that two conserved small GTPases, ARL-13 and ARL-3, coordinate to regulate intraflagellar transport and that perturbing this balance results in cilia deformation.
Title: The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F19H8.3 (e-PCR)
- UniSTS:316580

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ADP-ribosylation factor-like protein 3

NP_497037.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

14606472..14608342

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064636.4 → NP_497037.1 ADP-ribosylation factor-like protein 3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497037.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45379

Conserved Domains (2) summary

cd04155
Location:3 → 177

Arl3; Arf-like 3 (Arl3) GTPase

pfam00071
Location:19 → 175

Ras; Ras family