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    MAST4 microtubule associated serine/threonine kinase family member 4 [ Homo sapiens (human) ]

    Gene ID: 375449, updated on 14-Nov-2024

    Summary

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    Official Symbol
    MAST4provided by HGNC
    Official Full Name
    microtubule associated serine/threonine kinase family member 4provided by HGNC
    Primary source
    HGNC:HGNC:19037
    See related
    Ensembl:ENSG00000069020 MIM:618002; AllianceGenome:HGNC:19037
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the microtubule-associated serine/threonine protein kinases. The proteins in this family contain a domain that gives the kinase the ability to determine its own scaffold to control the effects of their kinase activities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
    Expression
    Ubiquitous expression in esophagus (RPKM 3.2), fat (RPKM 2.7) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MAST4 in Genome Data Viewer
    Location:
    5q12.3
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (66596393..67169593)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (67418473..67991744)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (65892221..66465421)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379002 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:65806587-65807786 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:65813935-65815134 Neighboring gene long intergenic non-protein coding RNA 2229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22619 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16064 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16067 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22621 Neighboring gene peptidylprolyl isomerase A pseudogene 78 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22622 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:66075742-66076941 Neighboring gene NANOG hESC enhancer GRCh37_chr5:66125559-66126060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16068 Neighboring gene NANOG hESC enhancer GRCh37_chr5:66137580-66138081 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:66145039-66146238 Neighboring gene Sharpr-MPRA regulatory region 1390 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:66199778-66200630 Neighboring gene Sharpr-MPRA regulatory region 14441 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16069 Neighboring gene Sharpr-MPRA regulatory region 14150 Neighboring gene MAST4 antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:66354795-66355337 Neighboring gene Sharpr-MPRA regulatory region 2367 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16070 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:66462629-66463134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22623 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22624 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:66501978-66503177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22625 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:66515108-66515295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22626 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:66528881-66529430 Neighboring gene CD180 molecule Neighboring gene TCL1A interacting lncRNA, retroperitoneal liposarcoma associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Nuclear MAST4 Suppresses FOXO3 through Interaction with AKT3 and Induces Chemoresistance in Pancreatic Ductal Carcinoma. Fujiwara-Tani R, et al. Int J Mol Sci, 2024 Apr 5. PMID 38612866, Free PMC Article
    2. [Identification of a novel human MAST4 gene, a new member of the microtubule associated serine-threonine kinase family]. Sun L, et al. Mol Biol (Mosk), 2006 Sep-Oct. PMID 17086981
    3. Estrogen-Responsive Gene MAST4 Regulates Myeloma Bone Disease. Cui Y, et al. J Bone Miner Res, 2022 Apr. PMID 35064934
    4. Clinical and genetic study of Tunisian families with genetic generalized epilepsy: contribution of CACNA1H and MAST4 genes. Landoulsi Z, et al. Neurogenetics, 2018 Aug. PMID 29948376
    5. MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis. Lee DJ, et al. Exp Mol Med, 2024 Jul. PMID 38945953, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis.
      Title: MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis.
    2. Nuclear MAST4 Suppresses FOXO3 through Interaction with AKT3 and Induces Chemoresistance in Pancreatic Ductal Carcinoma.
      Title: Nuclear MAST4 Suppresses FOXO3 through Interaction with AKT3 and Induces Chemoresistance in Pancreatic Ductal Carcinoma.
    3. Estrogen-Responsive Gene MAST4 Regulates Myeloma Bone Disease.
      Title: Estrogen-Responsive Gene MAST4 Regulates Myeloma Bone Disease.
    4. Mast4 knockout shows the regulation of spermatogonial stem cell self-renewal via the FGF2/ERM pathway.
      Title: Mast4 knockout shows the regulation of spermatogonial stem cell self-renewal via the FGF2/ERM pathway.
    5. Molecular studies incriminated different genes, mainly CACNA1H and MAST4. Since at least 2 susceptibility genes were likely shared by different populations, genetic factors involved in the majority of Tunisian Genetic generalized epilepsies families remain to be discovered.
      Title: Clinical and genetic study of Tunisian families with genetic generalized epilepsy: contribution of CACNA1H and MAST4 genes.
    6. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
      Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    8. high expression level of MAST4 in most normal human tissues, with an exception of in testis, small intestine, colon and peripheral blood leukocyte.
      Title: [Identification of a novel human MAST4 gene, a new member of the microtubule associated serine-threonine kinase family].
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of carotid atherosclerosis in HIV-infected men.
    EBI GWAS Catalog
    Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16540, FLJ33039, KIAA0303, DKFZp686N1467, DKFZp686E18148

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated serine/threonine-protein kinase 4
    NP_001158136.1
    NP_001277155.1
    NP_001277156.1
    NP_001277157.1
    NP_001284580.1
    NP_001380453.1
    NP_001380454.1
    NP_001380455.1
    NP_001380456.1
    NP_001380457.1
    NP_055998.1
    NP_942123.1
    XP_006714669.1
    XP_011541686.1
    XP_011541687.1
    XP_011541688.1
    XP_016864938.1
    XP_016864939.1
    XP_016864941.1
    XP_016864942.1
    XP_024301812.1
    XP_047273113.1
    XP_047273114.1
    XP_047273115.1
    XP_047273116.1
    XP_047273117.1
    XP_047273118.1
    XP_047273119.1
    XP_047273120.1
    XP_047273121.1
    XP_054208513.1
    XP_054208514.1
    XP_054208515.1
    XP_054208516.1
    XP_054208517.1
    XP_054208518.1
    XP_054208519.1
    XP_054208520.1
    XP_054208521.1
    XP_054208522.1
    XP_054208523.1
    XP_054208524.1
    XP_054208525.1
    XP_054208526.1
    XP_054208527.1
    XP_054208528.1
    XP_054208529.1
    XP_054208530.1
    XP_054208531.1
    XP_054208532.1
    XP_054208533.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034036.1 RefSeqGene

      Range
      5046..578246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001164664.2 → NP_001158136.1  microtubule-associated serine/threonine-protein kinase 4 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC008872, AC008920, AC016634, AC044799, AC092373
      Consensus CDS
      CCDS54861.1
      UniProtKB/Swiss-Prot
      A6NL49, B5ME48, E7EWQ5, J3QT34, O15021, Q05EE6, Q6ZN07, Q8N4X4, Q96LY3
      Related
      ENSP00000385727.1, ENST00000403625.7
      Conserved Domains (4) summary
      cd00992
      Location:1146 → 1224
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:569 → 848
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:258 → 531
      DUF1908; Domain of unknown function (DUF1908)
      cl26464
      Location:1811 → 2189
      Atrophin-1; Atrophin-1 family

    2. NM_001290226.2 → NP_001277155.1  microtubule-associated serine/threonine-protein kinase 4 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AB002301, AC044799, AK299538
      UniProtKB/Swiss-Prot
      O15021
      UniProtKB/TrEMBL
      B4DS23
      Conserved Domains (4) summary
      smart00220
      Location:364 → 637
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:940 → 1018
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:363 → 642
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:49 → 325
      DUF1908; Domain of unknown function (DUF1908)

    3. NM_001290227.2 → NP_001277156.1  microtubule-associated serine/threonine-protein kinase 4 isoform 5

      See identical proteins and their annotated locations for NP_001277156.1

      Status: REVIEWED

      Source sequence(s)
      AC044799, AK296707
      UniProtKB/TrEMBL
      B4DKT8
      Conserved Domains (4) summary
      PHA03247
      Location:1550 → 1928
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:885 → 963
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:375 → 654
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:64 → 337
      DUF1908; Domain of unknown function (DUF1908)

    4. NM_001290228.2 → NP_001277157.1  microtubule-associated serine/threonine-protein kinase 4 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC008872, AC092373, AY439222, BC033215, CB044105
      Consensus CDS
      CCDS78015.1
      UniProtKB/TrEMBL
      E7EX28, Q6T2V4
      Related
      ENSP00000384547.1, ENST00000406039.5

    5. NM_001297651.2 → NP_001284580.1  microtubule-associated serine/threonine-protein kinase 4 isoform 7

      See identical proteins and their annotated locations for NP_001284580.1

      Status: REVIEWED

      Source sequence(s)
      AC044799, AK057601, AK299706, AY830839, BF515864
      Consensus CDS
      CCDS75254.1
      UniProtKB/Swiss-Prot
      O15021
      UniProtKB/TrEMBL
      B4DSE5
      Related
      ENSP00000261569.7, ENST00000261569.11
      Conserved Domains (4) summary
      smart00220
      Location:376 → 649
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:952 → 1030
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:375 → 654
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:64 → 337
      DUF1908; Domain of unknown function (DUF1908)

    6. NM_001393524.1 → NP_001380453.1  microtubule-associated serine/threonine-protein kinase 4 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC008872, AC008920, AC016634, AC044799, AC092373
      Conserved Domains (3) summary
      PHA03247
      Location:1814 → 2192
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:1149 → 1227
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:572 → 851
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

    7. NM_001393525.1 → NP_001380454.1  microtubule-associated serine/threonine-protein kinase 4 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC008872, AC008920, AC016634, AC044799, AC092373
      Conserved Domains (3) summary
      PHA03247
      Location:1744 → 2122
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:1079 → 1157
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:569 → 848
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

    8. NM_001393526.1 → NP_001380455.1  microtubule-associated serine/threonine-protein kinase 4 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC008872, AC008920, AC016634, AC044799
      Conserved Domains (3) summary
      PHA03247
      Location:1555 → 1933
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:890 → 968
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:380 → 659
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

    9. NM_001393527.1 → NP_001380456.1  microtubule-associated serine/threonine-protein kinase 4 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC008872, AC008920, AC044799
      Conserved Domains (4) summary
      PHA03247
      Location:1550 → 1928
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:885 → 963
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:375 → 654
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:64 → 337
      DUF1908; Domain of unknown function (DUF1908)

    10. NM_001393528.1 → NP_001380457.1  microtubule-associated serine/threonine-protein kinase 4 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC008872, AC008920, AC016634, AC044799
      Conserved Domains (4) summary
      PHA03247
      Location:1543 → 1921
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:878 → 956
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:368 → 647
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:57 → 330
      DUF1908; Domain of unknown function (DUF1908)

    11. NM_015183.3 → NP_055998.1  microtubule-associated serine/threonine-protein kinase 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC016634, AC044799, AY830839
      Consensus CDS
      CCDS47225.1
      UniProtKB/Swiss-Prot
      O15021
      Related
      ENSP00000384313.1, ENST00000403666.5
      Conserved Domains (4) summary
      smart00220
      Location:381 → 654
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:957 → 1035
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:380 → 659
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:69 → 342
      DUF1908; Domain of unknown function (DUF1908)

    12. NM_198828.3 → NP_942123.1  microtubule-associated serine/threonine-protein kinase 4 isoform 2

      See identical proteins and their annotated locations for NP_942123.1

      Status: REVIEWED

      Source sequence(s)
      BC033215
      Consensus CDS
      CCDS47224.1
      UniProtKB/TrEMBL
      Q6T2V4
      Related
      ENSP00000385088.1, ENST00000406374.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      66596393..67169593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024446044.2 → XP_024301812.1  microtubule-associated serine/threonine-protein kinase 4 isoform X1

      Conserved Domains (4) summary
      cd00992
      Location:1218 → 1296
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:641 → 920
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:330 → 603
      DUF1908; Domain of unknown function (DUF1908)
      cl26464
      Location:1883 → 2261
      Atrophin-1; Atrophin-1 family

    2. XM_047417157.1 → XP_047273113.1  microtubule-associated serine/threonine-protein kinase 4 isoform X2

    3. XM_047417158.1 → XP_047273114.1  microtubule-associated serine/threonine-protein kinase 4 isoform X3

    4. XM_047417159.1 → XP_047273115.1  microtubule-associated serine/threonine-protein kinase 4 isoform X4

    5. XM_047417160.1 → XP_047273116.1  microtubule-associated serine/threonine-protein kinase 4 isoform X5

    6. XM_017009452.2 → XP_016864941.1  microtubule-associated serine/threonine-protein kinase 4 isoform X15

    7. XM_017009450.2 → XP_016864939.1  microtubule-associated serine/threonine-protein kinase 4 isoform X9

    8. XM_047417164.1 → XP_047273120.1  microtubule-associated serine/threonine-protein kinase 4 isoform X15

    9. XM_017009449.2 → XP_016864938.1  microtubule-associated serine/threonine-protein kinase 4 isoform X6

      Related
      ENSP00000384099.1, ENST00000405643.5

    10. XM_047417161.1 → XP_047273117.1  microtubule-associated serine/threonine-protein kinase 4 isoform X12

    11. XM_011543385.4 → XP_011541687.1  microtubule-associated serine/threonine-protein kinase 4 isoform X10

      Conserved Domains (4) summary
      smart00220
      Location:361 → 634
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:937 → 1015
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:360 → 639
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:49 → 322
      DUF1908; Domain of unknown function (DUF1908)

    12. XM_047417163.1 → XP_047273119.1  microtubule-associated serine/threonine-protein kinase 4 isoform X14

    13. XM_006714606.4 → XP_006714669.1  microtubule-associated serine/threonine-protein kinase 4 isoform X7

      See identical proteins and their annotated locations for XP_006714669.1

      UniProtKB/Swiss-Prot
      O15021
      Conserved Domains (4) summary
      smart00220
      Location:376 → 649
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:952 → 1030
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:375 → 654
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:64 → 337
      DUF1908; Domain of unknown function (DUF1908)

    14. XM_047417165.1 → XP_047273121.1  microtubule-associated serine/threonine-protein kinase 4 isoform X15

    15. XM_017009453.2 → XP_016864942.1  microtubule-associated serine/threonine-protein kinase 4 isoform X15

    16. XM_011543386.3 → XP_011541688.1  microtubule-associated serine/threonine-protein kinase 4 isoform X11

      Conserved Domains (4) summary
      smart00220
      Location:358 → 631
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:934 → 1012
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:357 → 636
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:46 → 319
      DUF1908; Domain of unknown function (DUF1908)

    17. XM_011543384.3 → XP_011541686.1  microtubule-associated serine/threonine-protein kinase 4 isoform X8

      Conserved Domains (4) summary
      smart00220
      Location:370 → 643
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00992
      Location:946 → 1024
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd05609
      Location:369 → 648
      STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
      pfam08926
      Location:58 → 331
      DUF1908; Domain of unknown function (DUF1908)

    18. XM_047417162.1 → XP_047273118.1  microtubule-associated serine/threonine-protein kinase 4 isoform X13

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      67418473..67991744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352538.1 → XP_054208513.1  microtubule-associated serine/threonine-protein kinase 4 isoform X1

    2. XM_054352539.1 → XP_054208514.1  microtubule-associated serine/threonine-protein kinase 4 isoform X2

    3. XM_054352540.1 → XP_054208515.1  microtubule-associated serine/threonine-protein kinase 4 isoform X3

    4. XM_054352541.1 → XP_054208516.1  microtubule-associated serine/threonine-protein kinase 4 isoform X4

    5. XM_054352542.1 → XP_054208517.1  microtubule-associated serine/threonine-protein kinase 4 isoform X5

    6. XM_054352547.1 → XP_054208522.1  microtubule-associated serine/threonine-protein kinase 4 isoform X9

    7. XM_054352543.1 → XP_054208518.1  microtubule-associated serine/threonine-protein kinase 4 isoform X6

    8. XM_054352550.1 → XP_054208525.1  microtubule-associated serine/threonine-protein kinase 4 isoform X12

    9. XM_054352548.1 → XP_054208523.1  microtubule-associated serine/threonine-protein kinase 4 isoform X10

    10. XM_054352556.1 → XP_054208531.1  microtubule-associated serine/threonine-protein kinase 4 isoform X14

    11. XM_054352551.1 → XP_054208526.1  microtubule-associated serine/threonine-protein kinase 4 isoform X16

    12. XM_054352553.1 → XP_054208528.1  microtubule-associated serine/threonine-protein kinase 4 isoform X16

    13. XM_054352552.1 → XP_054208527.1  microtubule-associated serine/threonine-protein kinase 4 isoform X16

    14. XM_054352554.1 → XP_054208529.1  microtubule-associated serine/threonine-protein kinase 4 isoform X16

    15. XM_054352545.1 → XP_054208520.1  microtubule-associated serine/threonine-protein kinase 4 isoform X7

    16. XM_054352544.1 → XP_054208519.1  microtubule-associated serine/threonine-protein kinase 4 isoform X7

    17. XM_054352557.1 → XP_054208532.1  microtubule-associated serine/threonine-protein kinase 4 isoform X15

    18. XM_054352558.1 → XP_054208533.1  microtubule-associated serine/threonine-protein kinase 4 isoform X15

    19. XM_054352549.1 → XP_054208524.1  microtubule-associated serine/threonine-protein kinase 4 isoform X11

    20. XM_054352546.1 → XP_054208521.1  microtubule-associated serine/threonine-protein kinase 4 isoform X8

    21. XM_054352555.1 → XP_054208530.1  microtubule-associated serine/threonine-protein kinase 4 isoform X13

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15021.4 GenPept UniProtKB/Swiss-Prot:O15021

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