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    HAUS7 HAUS augmin like complex subunit 7 [ Homo sapiens (human) ]

    Gene ID: 55559, updated on 2-Nov-2024

    Summary

    Official Symbol
    HAUS7provided by HGNC
    Official Full Name
    HAUS augmin like complex subunit 7provided by HGNC
    Primary source
    HGNC:HGNC:32979
    See related
    Ensembl:ENSG00000213397 MIM:300540; AllianceGenome:HGNC:32979
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UIP1; UCHL5IP
    Summary
    This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
    Expression
    Ubiquitous expression in skin (RPKM 11.4), spleen (RPKM 5.8) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See HAUS7 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (153447668..153495465, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (151721251..151769038, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (152713126..152760923, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21062 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:152677238-152677448 Neighboring gene PNMA family member 6E Neighboring gene ZFP92 zinc finger protein Neighboring gene ReSE screen-validated silencer GRCh37_chrX:152726424-152726582 Neighboring gene three prime repair exonuclease 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30034 Neighboring gene Sharpr-MPRA regulatory region 9358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152741433-152741972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152742168-152742668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152742669-152743169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152753877-152754691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152756808-152757380 Neighboring gene extracellular matrix protein X-linked, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30035 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30036 Neighboring gene biglycan Neighboring gene ATPase plasma membrane Ca2+ transporting 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152809330-152810182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152825847-152826631 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152831014-152831626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21064 Neighboring gene cyclin Q

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    General gene information

    Potential readthrough

    Included gene: TREX2

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables microtubule minus-end binding  
    enables protein binding PubMed 
    enables thioesterase binding PubMed 
    Process Evidence Code Pubs
    involved_in cell division  
    involved_in centrosome cycle PubMed 
    involved_in centrosome cycle PubMed 
    involved_in microtubule organizing center organization  
    involved_in regulation of microtubule nucleation PubMed 
    involved_in spindle assembly  
    involved_in spindle assembly PubMed 
    involved_in spindle assembly PubMed 
    Component Evidence Code Pubs
    part_of HAUS complex  
    part_of HAUS complex PubMed 
    part_of HAUS complex PubMed 
    located_in centrosome PubMed 
    located_in cytosol  
    located_in mitotic spindle microtubule PubMed 
    located_in nucleolus  
    located_in plasma membrane  

    General protein information

    Preferred Names
    HAUS augmin-like complex subunit 7
    Names
    26S proteasome-associated UCH37-interacting protein 1
    X-linked protein STS1769

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012688.3 RefSeqGene

      Range
      29895..52861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001385481.1NP_001372410.1  HAUS augmin-like complex subunit 7 isoform 2

      Status: REVIEWED

      Source sequence(s)
      U82695
    2. NM_001385482.1NP_001372411.1  HAUS augmin-like complex subunit 7 isoform 1

      Status: REVIEWED

      Source sequence(s)
      U82695
      Consensus CDS
      CCDS35438.2
      UniProtKB/Swiss-Prot
      B4DUH6, D3DWT9, Q96HS8, Q99871, Q9NP54, Q9UFH9
      Related
      ENSP00000359230.6, ENST00000370211.10
    3. NM_001385483.1NP_001372412.1  HAUS augmin-like complex subunit 7 isoform 2

      Status: REVIEWED

      Source sequence(s)
      U82695

    RNA

    1. NR_073156.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains multiple differences, compared to variant 1, including use of an alternate upstream promoter. This variant is represented as non-coding because the use of the translational start codon used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK125219, BC008141, DB248557, U82695
    2. NR_169630.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      U82695
    3. NR_169631.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      U82695

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      153447668..153495465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      151721251..151769038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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