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    ZMYM2 zinc finger MYM-type containing 2 [ Homo sapiens (human) ]

    Gene ID: 7750, updated on 14-Nov-2024

    Summary

    Official Symbol
    ZMYM2provided by HGNC
    Official Full Name
    zinc finger MYM-type containing 2provided by HGNC
    Primary source
    HGNC:HGNC:12989
    See related
    Ensembl:ENSG00000121741 MIM:602221; AllianceGenome:HGNC:12989
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FIM; MYM; RAMP; SCLL; NECRC; ZNF198
    Summary
    The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
    Expression
    Ubiquitous expression in testis (RPKM 14.1), thyroid (RPKM 6.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZMYM2 in Genome Data Viewer
    Location:
    13q12.11
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (19863840..20089115)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (19153836..19285569)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (20531563..20663255)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:20392071-20392598 Neighboring gene zinc finger MYM-type containing 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5140 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:20437895-20438623 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7413 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5142 Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:20531546-20532088 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:20532089-20532630 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5146 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:20533613-20534383 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5147 Neighboring gene KRR1 pseudogene 1 Neighboring gene uncharacterized LOC105370101 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7415 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5148 Neighboring gene long intergenic non-protein coding RNA 1072

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables ubiquitin conjugating enzyme binding PubMed 
    enables zinc ion binding PubMed 
    Component Evidence Code Pubs
    located_in PML body PubMed 
    located_in cytosol  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    zinc finger MYM-type protein 2
    Names
    fused in myeloproliferative disorders protein
    rearranged in an atypical myeloproliferative disorder
    zinc finger protein 198
    zinc finger, MYM-type 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023348.3 RefSeqGene

      Range
      99889..230277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001190964.4NP_001177893.1  zinc finger MYM-type protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001177893.1

      Status: REVIEWED

      Source sequence(s)
      AL137119, AL138688
      Consensus CDS
      CCDS45016.1
      UniProtKB/Swiss-Prot
      A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
      UniProtKB/TrEMBL
      A8K126
      Related
      ENSP00000372327.2, ENST00000382874.6
      Conserved Domains (2) summary
      pfam06467
      Location:462502
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:11921359
      DUF3504; Domain of unknown function (DUF3504)
    2. NM_001190965.4NP_001177894.1  zinc finger MYM-type protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001177894.1

      Status: REVIEWED

      Source sequence(s)
      AL137119, AL138688
      Consensus CDS
      CCDS45016.1
      UniProtKB/Swiss-Prot
      A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
      UniProtKB/TrEMBL
      A8K126
      Conserved Domains (2) summary
      pfam06467
      Location:462502
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:11921359
      DUF3504; Domain of unknown function (DUF3504)
    3. NM_001353157.2NP_001340086.1  zinc finger MYM-type protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL137119, AL138688
      Consensus CDS
      CCDS45016.1
      UniProtKB/Swiss-Prot
      A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
      UniProtKB/TrEMBL
      A8K126
      Conserved Domains (2) summary
      pfam06467
      Location:462502
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:11921359
      DUF3504; Domain of unknown function (DUF3504)
    4. NM_001353159.2NP_001340088.1  zinc finger MYM-type protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL137119, AL138688
      Consensus CDS
      CCDS45016.1
      UniProtKB/Swiss-Prot
      A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
      UniProtKB/TrEMBL
      A8K126
      Conserved Domains (2) summary
      pfam06467
      Location:462502
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:11921359
      DUF3504; Domain of unknown function (DUF3504)
    5. NM_001353161.3NP_001340090.1  zinc finger MYM-type protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL137119, AL138688
      UniProtKB/TrEMBL
      A8K126
      Conserved Domains (2) summary
      pfam06467
      Location:397437
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:11271294
      DUF3504; Domain of unknown function (DUF3504)
    6. NM_001353162.3NP_001340091.1  zinc finger MYM-type protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL137119, AL138688
      Consensus CDS
      CCDS45016.1
      UniProtKB/Swiss-Prot
      A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
      UniProtKB/TrEMBL
      A8K126
      Conserved Domains (2) summary
      pfam06467
      Location:462502
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:11921359
      DUF3504; Domain of unknown function (DUF3504)
    7. NM_001353163.2NP_001340092.1  zinc finger MYM-type protein 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL137119, AL138688
      UniProtKB/TrEMBL
      A8K126
      Conserved Domains (2) summary
      pfam06467
      Location:375415
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:11051272
      DUF3504; Domain of unknown function (DUF3504)
    8. NM_001353164.2NP_001340093.1  zinc finger MYM-type protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL137119, AL138688
      Consensus CDS
      CCDS45016.1
      UniProtKB/Swiss-Prot
      A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
      UniProtKB/TrEMBL
      A8K126
      Conserved Domains (2) summary
      pfam06467
      Location:462502
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:11921359
      DUF3504; Domain of unknown function (DUF3504)
    9. NM_001353165.2NP_001340094.1  zinc finger MYM-type protein 2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL137119
      UniProtKB/TrEMBL
      A8K126
      Conserved Domains (1) summary
      pfam06467
      Location:462502
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
    10. NM_003453.6NP_003444.1  zinc finger MYM-type protein 2 isoform 1

      See identical proteins and their annotated locations for NP_003444.1

      Status: REVIEWED

      Source sequence(s)
      AL137119, AL138688
      Consensus CDS
      CCDS45016.1
      UniProtKB/Swiss-Prot
      A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
      UniProtKB/TrEMBL
      A8K126
      Related
      ENSP00000372324.2, ENST00000382871.3
      Conserved Domains (2) summary
      pfam06467
      Location:462502
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:11921359
      DUF3504; Domain of unknown function (DUF3504)
    11. NM_197968.4NP_932072.1  zinc finger MYM-type protein 2 isoform 1

      See identical proteins and their annotated locations for NP_932072.1

      Status: REVIEWED

      Source sequence(s)
      AL137119, AL138688
      Consensus CDS
      CCDS45016.1
      UniProtKB/Swiss-Prot
      A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
      UniProtKB/TrEMBL
      A8K126
      Related
      ENSP00000479904.1, ENST00000610343.5
      Conserved Domains (2) summary
      pfam06467
      Location:462502
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:11921359
      DUF3504; Domain of unknown function (DUF3504)

    RNA

    1. NR_148365.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL137119, AL138688

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      19863840..20089115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430584.1XP_047286540.1  zinc finger MYM-type protein 2 isoform X1

    2. XM_047430585.1XP_047286541.1  zinc finger MYM-type protein 2 isoform X1

    3. XM_047430595.1XP_047286551.1  zinc finger MYM-type protein 2 isoform X5

    4. XM_047430587.1XP_047286543.1  zinc finger MYM-type protein 2 isoform X2

    5. XM_047430594.1XP_047286550.1  zinc finger MYM-type protein 2 isoform X4

    6. XM_024449406.2XP_024305174.1  zinc finger MYM-type protein 2 isoform X2

      UniProtKB/TrEMBL
      A8K126
      Conserved Domains (2) summary
      pfam06467
      Location:484524
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:12141381
      DUF3504; Domain of unknown function (DUF3504)
    7. XM_047430593.1XP_047286549.1  zinc finger MYM-type protein 2 isoform X4

    8. XM_017020731.1XP_016876220.1  zinc finger MYM-type protein 2 isoform X5

      UniProtKB/TrEMBL
      A8K126
      Conserved Domains (2) summary
      pfam06467
      Location:375415
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:11051272
      DUF3504; Domain of unknown function (DUF3504)
    9. XM_047430592.1XP_047286548.1  zinc finger MYM-type protein 2 isoform X4

    10. XM_047430591.1XP_047286547.1  zinc finger MYM-type protein 2 isoform X3

      UniProtKB/Swiss-Prot
      A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
    11. XM_047430599.1XP_047286555.1  zinc finger MYM-type protein 2 isoform X6

    12. XM_024449407.2XP_024305175.1  zinc finger MYM-type protein 2 isoform X7

      UniProtKB/TrEMBL
      A8K126
      Conserved Domains (1) summary
      pfam06467
      Location:484524
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
    13. XM_047430602.1XP_047286558.1  zinc finger MYM-type protein 2 isoform X11

    14. XM_047430586.1XP_047286542.1  zinc finger MYM-type protein 2 isoform X2

    15. XM_005266520.4XP_005266577.1  zinc finger MYM-type protein 2 isoform X3

      See identical proteins and their annotated locations for XP_005266577.1

      UniProtKB/Swiss-Prot
      A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
      UniProtKB/TrEMBL
      A8K126
      Conserved Domains (2) summary
      pfam06467
      Location:462502
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:11921359
      DUF3504; Domain of unknown function (DUF3504)
    16. XM_017020732.2XP_016876221.1  zinc finger MYM-type protein 2 isoform X5

      UniProtKB/TrEMBL
      A8K126
      Conserved Domains (2) summary
      pfam06467
      Location:375415
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:11051272
      DUF3504; Domain of unknown function (DUF3504)
    17. XM_047430589.1XP_047286545.1  zinc finger MYM-type protein 2 isoform X3

      UniProtKB/Swiss-Prot
      A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
    18. XM_047430598.1XP_047286554.1  zinc finger MYM-type protein 2 isoform X5

    19. XM_047430600.1XP_047286556.1  zinc finger MYM-type protein 2 isoform X8

    20. XM_047430601.1XP_047286557.1  zinc finger MYM-type protein 2 isoform X9

    21. XM_047430603.1XP_047286559.1  zinc finger MYM-type protein 2 isoform X12

    22. XM_047430588.1XP_047286544.1  zinc finger MYM-type protein 2 isoform X3

      UniProtKB/Swiss-Prot
      A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
    23. XM_047430590.1XP_047286546.1  zinc finger MYM-type protein 2 isoform X3

      UniProtKB/Swiss-Prot
      A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
    24. XM_047430597.1XP_047286553.1  zinc finger MYM-type protein 2 isoform X5

    25. XM_047430596.1XP_047286552.1  zinc finger MYM-type protein 2 isoform X5

    26. XM_011535223.3XP_011533525.1  zinc finger MYM-type protein 2 isoform X10

      Conserved Domains (2) summary
      pfam06467
      Location:120160
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:681848
      DUF3504; Domain of unknown function (DUF3504)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      19153836..19285569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374924.1XP_054230899.1  zinc finger MYM-type protein 2 isoform X13

    2. XM_054374936.1XP_054230911.1  zinc finger MYM-type protein 2 isoform X5

    3. XM_054374927.1XP_054230902.1  zinc finger MYM-type protein 2 isoform X2

    4. XM_054374933.1XP_054230908.1  zinc finger MYM-type protein 2 isoform X4

    5. XM_054374925.1XP_054230900.1  zinc finger MYM-type protein 2 isoform X2

    6. XM_054374934.1XP_054230909.1  zinc finger MYM-type protein 2 isoform X4

    7. XM_054374939.1XP_054230914.1  zinc finger MYM-type protein 2 isoform X5

    8. XM_054374932.1XP_054230907.1  zinc finger MYM-type protein 2 isoform X4

    9. XM_054374931.1XP_054230906.1  zinc finger MYM-type protein 2 isoform X3

      UniProtKB/Swiss-Prot
      A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
    10. XM_054374940.1XP_054230915.1  zinc finger MYM-type protein 2 isoform X6

    11. XM_054374941.1XP_054230916.1  zinc finger MYM-type protein 2 isoform X7

    12. XM_054374945.1XP_054230920.1  zinc finger MYM-type protein 2 isoform X14

    13. XM_054374946.1XP_054230921.1  zinc finger MYM-type protein 2 isoform X11

    14. XM_054374926.1XP_054230901.1  zinc finger MYM-type protein 2 isoform X2

    15. XM_054374928.1XP_054230903.1  zinc finger MYM-type protein 2 isoform X3

      UniProtKB/Swiss-Prot
      A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
    16. XM_054374935.1XP_054230910.1  zinc finger MYM-type protein 2 isoform X5

    17. XM_054374942.1XP_054230917.1  zinc finger MYM-type protein 2 isoform X8

    18. XM_054374943.1XP_054230918.1  zinc finger MYM-type protein 2 isoform X9

    19. XM_054374947.1XP_054230922.1  zinc finger MYM-type protein 2 isoform X12

    20. XM_054374929.1XP_054230904.1  zinc finger MYM-type protein 2 isoform X3

      UniProtKB/Swiss-Prot
      A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
    21. XM_054374930.1XP_054230905.1  zinc finger MYM-type protein 2 isoform X3

      UniProtKB/Swiss-Prot
      A6NDG0, A6NI02, O43212, O43434, O60898, Q5W0Q4, Q5W0T3, Q63HP0, Q8NE39, Q9H0V5, Q9H538, Q9UBW7, Q9UEU2
    22. XM_054374938.1XP_054230913.1  zinc finger MYM-type protein 2 isoform X5

    23. XM_054374937.1XP_054230912.1  zinc finger MYM-type protein 2 isoform X5

    24. XM_054374944.1XP_054230919.1  zinc finger MYM-type protein 2 isoform X10

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