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    TUB4 gamma-tubulin [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850909, updated on 29-Jun-2024

    Summary

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    Gene symbol
    TUB4
    Gene description
    gamma-tubulin
    Primary source
    FungiDB:YLR212C
    Locus tag
    YLR212C
    See related
    SGD:S000004202; AllianceGenome:SGD:S000004202; VEuPathDB:YLR212C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    A structural constituent of cytoskeleton. Involved in microtubule nucleation by spindle pole body; mitotic spindle organization; and positive regulation of cytoplasmic translation. Located in inner plaque of spindle pole body and outer plaque of spindle pole body. Part of gamma-tubulin small complex. Used to study complex cortical dysplasia with other brain malformations 4. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 4; inclusion body myositis; and muscular disease. Orthologous to several human genes including TUBG2 (tubulin gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TUB4 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (564860..566281, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene B-type cyclin CLB4 Neighboring gene Atg38p Neighboring gene putative glycosylase Neighboring gene ferric/cupric-chelate reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Concerted millisecond timescale dynamics in the intrinsically disordered carboxyl terminus of γ-tubulin induced by mutation of a conserved tyrosine residue. Harris J, et al. Protein Sci, 2018 Feb. PMID 29127738, Free PMC Article
    2. Distinct roles for antiparallel microtubule pairing and overlap during early spindle assembly. Nazarova E, et al. Mol Biol Cell, 2013 Oct. PMID 23966467, Free PMC Article
    3. Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly. Poirier K, et al. Nat Genet, 2013 Jun. PMID 23603762, Free PMC Article
    4. Phosphorylation of gamma-tubulin regulates microtubule organization in budding yeast. Vogel J, et al. Dev Cell, 2001 Nov. PMID 11709183
    5. Analysis of Tub4p, a yeast gamma-tubulin-like protein: implications for microtubule-organizing center function. Marschall LG, et al. J Cell Biol, 1996 Jul. PMID 8707828, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings revealed that Rok1 protein synthesis is repressed by Psk2 and Skp1; this repression appeared to be mediated through the ROK1 uORF1; Tub4 plays a positive role in regulating Rok1 protein synthesis and likely after the uORF1-mediated inhibitory regulation
      Title: Identification of Psk2, Skp1, and Tub4 as trans-acting factors for uORF-containing ROK1 mRNA in Saccharomyces cerevisiae.
    2. The structure of the Saccharomyces cerevisiae gamma-tubulin small complex at 25-A resolution by electron microscopy, is determined.
      Title: The structure of the gamma-tubulin small complex: implications of its architecture and flexibility for microtubule nucleation.
    3. We propose that SPBs, via the tail of Tub4, promote the assembly of functional +TIP complexes before their deployment to microtubule +ends.
      Title: Gamma-tubulin is required for proper recruitment and assembly of Kar9-Bim1 complexes in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule nucleation by spindle pole body IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of gamma-tubulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-tubulin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of gamma-tubulin small complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of gamma-tubulin small complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in inner plaque of spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer plaque of spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole body HDA PubMed 
    is_active_in spindle pole body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gamma-tubulin
    NP_013313.1
    • Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress; null mutation is complemented by human TUBG1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      564860..566281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182099.1 → NP_013313.1  TPA: gamma-tubulin [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013313.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYL3, P53378
      UniProtKB/TrEMBL
      A0A8H4BZN3, A7A1A0, B3RHA1, B5VND0, C7GIU1, C8ZDH6, G2WJ42, N1P6V4
      Conserved Domains (1) summary
      COG5023
      Location:2 → 456
      COG5023; Tubulin [Cytoskeleton]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53378.1

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