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    Apoc1 apolipoprotein C1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25292, updated on 2-Nov-2024

    Summary

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    Symbol
    Apoc1provided by RGD
    Full Name
    apolipoprotein C1provided by RGD
    Primary source
    RGD:2134
    See related
    AllianceGenome:RGD:2134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ALPCI; LRRG04; Apo-CIB; ApoC-IB
    Summary
    Predicted to enable fatty acid binding activity and phospholipase inhibitor activity. Involved in regulation of lipid transport. Part of high-density lipoprotein particle and very-low-density lipoprotein particle. Human ortholog(s) of this gene implicated in Alzheimer's disease and obesity. Orthologous to human APOC1 (apolipoprotein C1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 23072.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Apoc1 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (88475018..88479052, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (79347057..79350340, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) Unplaced Scaffold NW_007906487.1 (10689..11406)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein C2 Neighboring gene apolipoprotein C4 Neighboring gene apolipoprotein E Neighboring gene translocase of outer mitochondrial membrane 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence of cDNA for rat apolipoprotein C-I. Shen PY, et al. Nucleic Acids Res, 1989 Aug 11. PMID 2771655, Free PMC Article
    2. Human apoA-I expression in CETP transgenic rats leads to lower levels of apoC-I in HDL and to magnification of CETP-mediated lipoprotein changes. Masson D, et al. J Lipid Res, 2006 Feb. PMID 16282639
    3. Stromal responses to carcinomas of the pancreas: juxtatumoral gene expression conforms to the infiltrating pattern and not the biologic subtype. Ricci F, et al. Cancer Biol Ther, 2005 Mar. PMID 15876873
    4. Very low-density lipoprotein-apoprotein CI is increased in diabetic nephropathy: comparison with apoprotein CIII. Hirano T, et al. Kidney Int, 2003 Jun. PMID 12753304
    5. Genetic association of an apolipoprotein C-I (APOC1) gene polymorphism with late-onset Alzheimer's disease. Ki CS, et al. Neurosci Lett, 2002 Feb 15. PMID 11825674

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chylomicron remnant clearance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipoprotein metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipoprotein metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cholesterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of lipoprotein lipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of phosphatidylcholine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of very-low-density lipoprotein particle clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of very-low-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid efflux ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasma lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lipid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in triglyceride metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within triglyceride metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very-low-density lipoprotein particle clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very-low-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of high-density lipoprotein particle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of high-density lipoprotein particle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of very-low-density lipoprotein particle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of very-low-density lipoprotein particle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of very-low-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    apolipoprotein C-I
    Names
    apo-CI
    apoC-I
    liver regeneration-related protein LRRG04

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109996.1 → NP_001103466.1  apolipoprotein C-I precursor

      See identical proteins and their annotated locations for NP_001103466.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an additional 5' non-coding exon, therefore, has a different 5' UTR compared to transcript variant 1. Transcript variants 1 and 2 encode the same protein.
      Source sequence(s)
      AY327505, BC098670
      UniProtKB/Swiss-Prot
      P19939, Q53ZD8
      UniProtKB/TrEMBL
      A6J8R3
      Conserved Domains (1) summary
      pfam04691
      Location:27 → 86
      ApoC-I; Apolipoprotein C-I (ApoC-1)

    2. NM_012824.2 → NP_036956.1  apolipoprotein C-I precursor

      See identical proteins and their annotated locations for NP_036956.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Transcript variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC098670, X15512
      UniProtKB/Swiss-Prot
      P19939, Q53ZD8
      UniProtKB/TrEMBL
      A6J8R3
      Conserved Domains (1) summary
      pfam04691
      Location:27 → 86
      ApoC-I; Apolipoprotein C-I (ApoC-1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      88475018..88479052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281631.1 → XP_063137701.1  apolipoprotein C-I isoform X1

      UniProtKB/Swiss-Prot
      P19939, Q53ZD8
      UniProtKB/TrEMBL
      A6J8R3

    2. XM_063281630.1 → XP_063137700.1  apolipoprotein C-I isoform X1

      UniProtKB/Swiss-Prot
      P19939, Q53ZD8
      UniProtKB/TrEMBL
      A6J8R3

    3. XM_063281632.1 → XP_063137702.1  apolipoprotein C-I isoform X1

      UniProtKB/Swiss-Prot
      P19939, Q53ZD8
      UniProtKB/TrEMBL
      A6J8R3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19939.1 GenPept UniProtKB/Swiss-Prot:P19939

    Gene LinkOut

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