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    Tm4sf4 transmembrane 4 L six family member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116467, updated on 17-Aug-2024

    Summary

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    Symbol
    Tm4sf4provided by RGD
    Full Name
    transmembrane 4 L six family member 4provided by RGD
    Primary source
    RGD:621784
    See related
    EnsemblRapid:ENSRNOG00000016437 AllianceGenome:RGD:621784
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lrtm4
    Summary
    Involved in tissue regeneration. Predicted to be integral component of membrane. Orthologous to human TM4SF4 (transmembrane 4 L six family member 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 907.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q26
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (143720220..143771283)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (141570321..141621263)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (147532032..147547254)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene minichromosome maintenance complex component 4, pseudogene 1 Neighboring gene WW domain containing transcription regulator 1 Neighboring gene ribosomal protein L12, pseudogene 2 Neighboring gene COMM domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Overexpression of the gene for transmembrane 4 superfamily member 4 accelerates liver damage in rats treated with CCl4. Qiu J, et al. J Hepatol, 2007 Feb. PMID 17069928
    2. Molecular cloning of a cDNA for rat TM4SF4, a homolog of human il-TMP (TM4SF4), and enhanced expression of the corresponding gene in regenerating rat liver(1). Liu Z, et al. Biochim Biophys Acta, 2001 Mar 19. PMID 11267677
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in tissue regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane 4 L6 family member 4
    Names
    transmembrane 4 superfamily member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053785.2 → NP_446237.1  transmembrane 4 L6 family member 4

      See identical proteins and their annotated locations for NP_446237.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q9EQL5
      UniProtKB/TrEMBL
      A6JVG1
      Conserved Domains (1) summary
      pfam05805
      Location:1 → 186
      L6_membrane; L6 membrane protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      143720220..143771283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281154.1 → XP_063137224.1  transmembrane 4 L6 family member 4 isoform X1

      UniProtKB/Swiss-Prot
      Q9EQL5
      UniProtKB/TrEMBL
      A6JVG1

    2. XM_039101566.2 → XP_038957494.1  transmembrane 4 L6 family member 4 isoform X1

      UniProtKB/Swiss-Prot
      Q9EQL5
      UniProtKB/TrEMBL
      A6JVG1
      Related
      ENSRNOP00000022105.3, ENSRNOT00000022105.6
      Conserved Domains (1) summary
      pfam05805
      Location:1 → 186
      L6_membrane; L6 membrane protein

    3. XM_063281155.1 → XP_063137225.1  transmembrane 4 L6 family member 4 isoform X1

      UniProtKB/Swiss-Prot
      Q9EQL5
      UniProtKB/TrEMBL
      A6JVG1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQL5.1 GenPept UniProtKB/Swiss-Prot:Q9EQL5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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