Pvr PVR cell adhesion molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pvrprovided by RGD
Official Full Name: PVR cell adhesion moleculeprovided by RGD
Primary source: RGD:3813
See related: EnsemblRapid:ENSRNOG00000019202 AllianceGenome:RGD:3813
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Taa1; Tage4
Summary: Enables virus receptor activity. Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and positive regulation of leukocyte mediated cytotoxicity. Predicted to act upstream of or within cell migration and cell-cell adhesion. Predicted to be located in cell surface and plasma membrane. Predicted to be active in adherens junction. Orthologous to human PVR (PVR cell adhesion molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 65.2), Heart (RPKM 42.8) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1q21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (88689235..88704641, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (79561294..79576700, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (80820306..80835712, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

report the in vivo induction of necl-5 in hepatocytes and provide evidence that both necl-5 mRNA and protein are tightly regulated in adult epithelial cells and tissue.
Title: Tightly regulated induction of the adhesion molecule necl-5/CD155 during rat liver regeneration and acute liver injury.
High Necl-5 is associated with glioblastoma.
Title: Inhibition of Necl-5 (CD155/PVR) reduces glioblastoma dispersal and decreases MMP-2 expression and activity.

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General gene information

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Markers

RH142229 (e-PCR)
- UniSTS:231479

RH133112 (e-PCR)
- UniSTS:216395

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables dynein light chain binding	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	ISO Inferred from Sequence Orthology more info
involved_in susceptibility to T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in susceptibility to natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: PVR cell adhesion molecule

Names: poliovirus receptor; tumor-associated antigen 1; tumor-associated glycoprotein E4; tumor-associated glycoprotein pE4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017076.2 → NP_058772.2 PVR cell adhesion molecule precursor

See identical proteins and their annotated locations for NP_058772.2

Status: PROVISIONAL

Source sequence(s)

BC085741

UniProtKB/TrEMBL

A6J8V8, F7FK02, Q5U334, Q9R1E1

Related

ENSRNOP00000061458.1, ENSRNOT00000064305.5

Conserved Domains (3) summary

cd05718
Location:49 → 148

Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins

smart00410
Location:41 → 148

IG_like; Immunoglobulin like

cl11960
Location:152 → 246

Ig; Immunoglobulin domain