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    Ift52 intraflagellar transport 52 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362265, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ift52provided by RGD
    Official Full Name
    intraflagellar transport 52provided by RGD
    Primary source
    RGD:1311004
    See related
    EnsemblRapid:ENSRNOG00000007692 AllianceGenome:RGD:1311004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311004
    Summary
    Predicted to be involved in cilium assembly and intraciliary anterograde transport. Predicted to act upstream of or within several processes, including embryonic morphogenesis; negative regulation of keratinocyte proliferation; and non-motile cilium assembly. Predicted to be located in several cellular components, including ciliary base; ciliary tip; and microtubule organizing center. Predicted to be part of intraciliary transport particle B. Predicted to be active in centriole and cilium. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy. Orthologous to human IFT52 (intraflagellar transport 52). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 158.3), Adrenal (RPKM 139.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ift52 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (172091591..172116497)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (151672505..151696975)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (159388868..159413358)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene L3MBTL histone methyl-lysine binding protein 1 Neighboring gene serum/glucocorticoid regulated kinase 2 Neighboring gene uncharacterized LOC120101778 Neighboring gene 5S ribosomal RNA Neighboring gene MYB proto-oncogene like 2 Neighboring gene gametocyte specific factor 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. IFT52 mutations destabilize anterograde complex assembly, disrupt ciliogenesis and result in short rib polydactyly syndrome. Zhang W, et al. Hum Mol Genet, 2016 Sep 15. PMID 27466190, Free PMC Article
    2. The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly. Follit JA, et al. Mol Biol Cell, 2006 Sep. PMID 16775004, Free PMC Article
    3. Intraflagellar transport molecules in ciliary and nonciliary cells of the retina. Sedmak T, et al. J Cell Biol, 2010 Apr 5. PMID 20368623, Free PMC Article
    4. Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Liu A, et al. Development, 2005 Jul. PMID 15930098
    5. SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium. Dharmat R, et al. J Cell Biol, 2018 Aug 6. PMID 29899041, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dorsal/ventral pattern formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic digit morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart looping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intraciliary anterograde transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary base ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary tip ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle B ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor cell cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor connecting cilium ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    intraflagellar transport protein 52 homolog
    Names
    intraflagellar transport 52 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308389.1 → NP_001295318.1  intraflagellar transport protein 52 homolog

      See identical proteins and their annotated locations for NP_001295318.1

      Status: VALIDATED

      Source sequence(s)
      BC162007, JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JX12, D4A5T7
      Conserved Domains (1) summary
      cl23805
      Location:17 → 116
      ABC_transp_aux; ABC-type uncharacterized transport system

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      172091591..172116497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284213.1 → XP_063140283.1  intraflagellar transport protein 52 homolog isoform X2

      UniProtKB/TrEMBL
      A6JX12
      Related
      ENSRNOP00000059169.4, ENSRNOT00000066260.5

    2. XM_063284211.1 → XP_063140281.1  intraflagellar transport protein 52 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y075
      Related
      ENSRNOP00000076599.1, ENSRNOT00000113137.2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001177685.1: Suppressed sequence

      Description
      NM_001177685.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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