Spart spartin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spartprovided by RGD
Official Full Name: spartinprovided by RGD
Primary source: RGD:1305900
See related: EnsemblRapid:ENSRNOG00000014155 AllianceGenome:RGD:1305900
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Spg20
Summary: Predicted to enable lipid binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including abscission; lipophagy; and negative regulation of BMP signaling pathway. Predicted to act upstream of or within several processes, including adipose tissue development; lipid droplet organization; and negative regulation of collateral sprouting in absence of injury. Predicted to be located in several cellular components, including lipid droplet; midbody; and mitochondrial outer membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Troyer syndrome. Orthologous to human SPART (spartin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 137.7), Muscle (RPKM 103.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q26

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (141442770..141469388)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (139292630..139319248)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (144522382..144548968)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

stSG602277 (e-PCR)
- UniSTS:444999

RH128776 (e-PCR)
- UniSTS:212084

RH133742 (e-PCR)
- UniSTS:217025

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in cell division	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	ISO Inferred from Sequence Orthology more info
acts_upstream_of collateral sprouting in absence of injury	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid droplet organization	ISO Inferred from Sequence Orthology more info
involved_in lipid transport	ISO Inferred from Sequence Orthology more info
involved_in lipophagy	ISO Inferred from Sequence Orthology more info
involved_in midbody abscission	IEA Inferred from Electronic Annotation more info
involved_in midbody abscission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of collateral sprouting in absence of injury	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: spartin

Names: spastic paraplegia 20 (Troyer syndrome) homolog; spastic paraplegia 20, spartin (Troyer syndrome) homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106433.3 → NP_001099903.3 spartin

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6JVE5

Related

ENSRNOP00000078817.1, ENSRNOT00000116850.2

Conserved Domains (2) summary

cd02679
Location:16 → 95

MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...

pfam06911
Location:434 → 618

Senescence; Senescence-associated protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

141442770..141469388

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006232367.5 → XP_006232429.2 spartin isoform X3

UniProtKB/TrEMBL

A6JVE5

Conserved Domains (2) summary

cd02679
Location:16 → 95

MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...

pfam06911
Location:434 → 618

Senescence; Senescence-associated protein
XM_006232365.5 → XP_006232427.2 spartin isoform X1

UniProtKB/TrEMBL

A6JVE5

Conserved Domains (2) summary

cd02679
Location:27 → 106

MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...

pfam06911
Location:445 → 629

Senescence; Senescence-associated protein
XM_006232366.5 → XP_006232428.2 spartin isoform X2

UniProtKB/TrEMBL

A6JVE5

Related

ENSRNOP00000054787.6, ENSRNOT00000057978.6

Conserved Domains (2) summary

cd02679
Location:24 → 103

MIT_spastin; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in the AAA protein spastin, a probable ATPase involved in the assembly or function of nuclear protein complexes; spastins might also be ...

pfam06911
Location:442 → 626

Senescence; Senescence-associated protein