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    Tmub1 transmembrane and ubiquitin-like domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362301, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Tmub1provided by RGD
    Official Full Name
    transmembrane and ubiquitin-like domain containing 1provided by RGD
    Primary source
    RGD:735120
    See related
    AllianceGenome:RGD:735120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hops
    Summary
    The protein encoded by this gene belongs to a group of integral ubiquitin-like domain containing proteins that are involved in a range of cellular processes. In mouse, the protein exists in uncleaved transmembrane forms as well as a cleaved form that shuttles between the nucleus and cytoplasm. During liver regeneration in rat, it has been shown that the protein shuttles from the cytoplasm to the nucleus to inhibit hepatocyte proliferation. Homozygous null mutant mice display normal development and physiology but exhibit a strong increase in locomoter activity during the dark phase of the light:dark cycle, indicating a function in behavioral regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
    Expression
    Biased expression in Kidney (RPKM 45.3), Thymus (RPKM 41.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (11621931..11624497)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (10729494..10732060)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7257752..7260318)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene gastrulation brain homeobox 1 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Neighboring gene uncharacterized LOC134486542 Neighboring gene Fas-activated serine/threonine kinase Neighboring gene solute carrier family 4 member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Microarray analysis reveals Tmub1 as a cell cycle-associated protein in rat hepatocytes. Fu H, et al. Mol Med Rep, 2018 Mar. PMID 29344642, Free PMC Article
    2. CCAAT/enhancer-binding protein β regulates interleukin-6-induced transmembrane and ubiquitin-like domain containing 1 gene expression in hepatocytes. Liu M, et al. Mol Med Rep, 2014 Oct. PMID 25109894
    3. TMUB1 Inhibits BRL-3A Hepatocyte Proliferation by Interfering with the Binding of CAML to Cyclophilin B through its TM1 Hydrophobic Domain. Lan X, et al. Sci Rep, 2018 Jul 2. PMID 29967478, Free PMC Article
    4. MiR-27a/b Regulates Liver Regeneration by Posttranscriptional Modification of Tmub1. Lan X, et al. Dig Dis Sci, 2018 Sep. PMID 29777440
    5. IL-6 induction of hepatocyte proliferation through the Tmub1-regulated gene pathway. Liu M, et al. Int J Mol Med, 2012 Jun. PMID 22426572

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMUB1 regulates hepatocyte proliferation by interacting with CAML and further interferes with the binding of CAML to cyclophilin B.
      Title: TMUB1 Inhibits BRL-3A Hepatocyte Proliferation by Interfering with the Binding of CAML to Cyclophilin B through its TM1 Hydrophobic Domain.
    2. MiR-27a/b regulates hepatocyte proliferation by controlling posttranscriptional modification of Tmub1 during liver regeneration.
      Title: MiR-27a/b Regulates Liver Regeneration by Posttranscriptional Modification of Tmub1.
    3. The transcriptional profile and potential biological processes affected by Tmub1 expression in hepatocytes have been reported.
      Title: Microarray analysis reveals Tmub1 as a cell cycle-associated protein in rat hepatocytes.
    4. HOPS has distinct, isoform-specific functions in the nucleolus, nucleus, and cytoplasm.
      Title: Different functions of HOPS isoforms in the cell: HOPS shuttling isoform is determined by RIP cleavage system.
    5. Tmub1 plays a negative role in IL-6-induced hepatocyte proliferation.
      Title: IL-6 induction of hepatocyte proliferation through the Tmub1-regulated gene pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72996

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynaptic neurotransmitter receptor internalization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane and ubiquitin-like domain-containing protein 1
    Names
    hepatocyte odd protein shuttling protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080153.2 → NP_001073622.1  transmembrane and ubiquitin-like domain-containing protein 1

      See identical proteins and their annotated locations for NP_001073622.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      DY313123, JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q53AQ4
      Conserved Domains (1) summary
      cd17131
      Location:101 → 171
      Ubl_TMUB1; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1)

    2. NM_198781.3 → NP_942076.2  transmembrane and ubiquitin-like domain-containing protein 1

      See identical proteins and their annotated locations for NP_942076.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate exon in the 5' UTR compared to variant 2. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      DY313123, JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q53AQ4
      Conserved Domains (1) summary
      cd17131
      Location:101 → 171
      Ubl_TMUB1; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      11621931..11624497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235945.5 → XP_006236007.1  transmembrane and ubiquitin-like domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006236007.1

      UniProtKB/Swiss-Prot
      Q53AQ4
      Conserved Domains (1) summary
      cd17131
      Location:101 → 171
      Ubl_TMUB1; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q53AQ4.1 GenPept UniProtKB/Swiss-Prot:Q53AQ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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