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    Slc66a2 solute carrier family 66 member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361352, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc66a2provided by RGD
    Official Full Name
    solute carrier family 66 member 2provided by RGD
    Primary source
    RGD:1305223
    See related
    EnsemblRapid:ENSRNOG00000059215 AllianceGenome:RGD:1305223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pqlc1
    Summary
    Predicted to be involved in phospholipid translocation and retrograde transport, endosome to Golgi. Predicted to be located in cytosol and membrane. Predicted to be active in endosome and trans-Golgi network. Orthologous to human SLC66A2 (solute carrier family 66 member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 168.8), Liver (RPKM 158.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc66a2 in Genome Data Viewer
    Location:
    18q12.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (75976000..76014651)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (73702472..73739678)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (76768466..76805773)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene thioredoxin-like 4A Neighboring gene N(alpha)-acetyltransferase 12, NatA catalytic subunit Neighboring gene heat shock factor binding protein 1-like 1 Neighboring gene potassium voltage-gated channel modifier subfamily G member 2 Neighboring gene uncharacterized LOC120098179 Neighboring gene uncharacterized LOC134482964

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 66 member 2
    Names
    PQ loop repeat containing 1
    PQ-loop repeat-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398665.1 → NP_001385594.1  solute carrier family 66 member 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8L2UR94, A6K5H3
      Conserved Domains (1) summary
      pfam04193
      Location:152 → 212
      PQ-loop; PQ loop repeat

    2. NM_001398666.1 → NP_001385595.1  solute carrier family 66 member 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8L2UR94, A6K5H3
      Related
      ENSRNOP00000074262.2, ENSRNOT00000089389.3
      Conserved Domains (1) summary
      pfam04193
      Location:152 → 212
      PQ-loop; PQ loop repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      75976000..76014651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254952.5 → XP_006255014.1  solute carrier family 66 member 2 isoform X1

      See identical proteins and their annotated locations for XP_006255014.1

      UniProtKB/Swiss-Prot
      Q5M880
      UniProtKB/TrEMBL
      A6K5H2
      Conserved Domains (1) summary
      pfam04193
      Location:170 → 230
      PQ-loop; PQ loop repeat

    2. XM_006254953.5 → XP_006255015.1  solute carrier family 66 member 2 isoform X1

      See identical proteins and their annotated locations for XP_006255015.1

      UniProtKB/Swiss-Prot
      Q5M880
      UniProtKB/TrEMBL
      A6K5H2
      Related
      ENSRNOP00000086993.1, ENSRNOT00000114669.2
      Conserved Domains (1) summary
      pfam04193
      Location:170 → 230
      PQ-loop; PQ loop repeat

    3. XM_063277484.1 → XP_063133554.1  solute carrier family 66 member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8L2UR94, A6K5H3

    4. XM_017601004.3 → XP_017456493.1  solute carrier family 66 member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5M880
      UniProtKB/TrEMBL
      A6K5H2
      Conserved Domains (1) summary
      pfam04193
      Location:170 → 230
      PQ-loop; PQ loop repeat

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013189.2: Suppressed sequence

      Description
      NM_001013189.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M880.2 GenPept UniProtKB/Swiss-Prot:Q5M880

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials