Fos Fos proto-oncogene, AP-1 transcription factor subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fosprovided by RGD
Official Full Name: Fos proto-oncogene, AP-1 transcription factor subunitprovided by RGD
Primary source: RGD:2626
See related: EnsemblRapid:ENSRNOG00000008015 AllianceGenome:RGD:2626
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: c-fos
Summary: Enables DNA binding activity; DNA-binding transcription factor activity; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; learning or memory; and nervous system development. Located in endoplasmic reticulum; nuclear matrix; and nucleoplasm. Used to study alcohol dependence; alcohol use disorder; gastric ulcer; and morphine dependence. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); brain disease (multiple); and drug dependence (multiple). Orthologous to human FOS (Fos proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 63.6), Muscle (RPKM 50.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q31

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (110852188..110855054)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (105121170..105124036)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (109300433..109303299)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chronic Variable Stress and Cafeteria Diet Combination Exacerbate Microglia and c-fos Activation but Not Experimental Anxiety or Depression in a Menopause Model.
Title: Chronic Variable Stress and Cafeteria Diet Combination Exacerbate Microglia and c-fos Activation but Not Experimental Anxiety or Depression in a Menopause Model.
Environmental Enrichment during Abstinence Reduces Oxycodone Seeking and c-Fos Expression in a Subpopulation of Medial Prefrontal Cortex Neurons.
Title: Environmental Enrichment during Abstinence Reduces Oxycodone Seeking and c-Fos Expression in a Subpopulation of Medial Prefrontal Cortex Neurons.
Social play exclusion model in adolescent rats: Monitoring locomotor and emotional behavior associated with social play and examining c-Fos expression in the brain.
Title: Social play exclusion model in adolescent rats: Monitoring locomotor and emotional behavior associated with social play and examining c-Fos expression in the brain.
c-Fos expression after neonatal handling in social brain regions: Distinctive profile of RHA-rat schizophrenia model on a social preference test.
Title: c-Fos expression after neonatal handling in social brain regions: Distinctive profile of RHA-rat schizophrenia model on a social preference test.
The increase in c-fos expression in epileptic seizures is inhibited by magnetic field application, but not KCa1.1 channel expression.
Title: The increase in c-fos expression in epileptic seizures is inhibited by magnetic field application, but not K(Ca)1.1 channel expression.
Oral carcinogenesis triggers a nociceptive behavior and c-Fos expression in rats' trigeminal pathway.
Title: Oral carcinogenesis triggers a nociceptive behavior and c-Fos expression in rats' trigeminal pathway.
Fluoride impairs mitochondrial translation by targeting miR-221-3p/c-Fos/RMND1 axis contributing to neurodevelopment defects.
Title: Fluoride impairs mitochondrial translation by targeting miR-221-3p/c-Fos/RMND1 axis contributing to neurodevelopment defects.
Generation of c-Fos knockout rats, and observation of their phenotype.
Title: Generation of c-Fos knockout rats, and observation of their phenotype.
Orthodontic pain: c-Fos expression in rat brain nuclei after rapid maxillary expansion.
Title: Orthodontic pain: c-Fos expression in rat brain nuclei after rapid maxillary expansion.
Chronic mild stress induces differential depression-like symptoms and c-Fos and 5HT1A protein levels in high-anxiety female Long Evans rats.
Title: Chronic mild stress induces differential depression-like symptoms and c-Fos and 5HT1A protein levels in high-anxiety female Long Evans rats.

Submit: New GeneRIF Correction See all GeneRIFs (358)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-19801 (e-PCR)
- UniSTS:18950

Fos (e-PCR), detects polymorphism
- UniSTS:143124

Fos (e-PCR), detects polymorphism
- UniSTS:143125

PMC99986P2 (e-PCR)
- UniSTS:273714

BP240034A10G4 (e-PCR)
- UniSTS:519219

PMC108124P1 (e-PCR)
- UniSTS:270133

PMC151804P3 (e-PCR)
- UniSTS:271177

Fos (e-PCR), detects polymorphism
- UniSTS:256935

PMC321436P2 (e-PCR)
- UniSTS:273107

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables R-SMAD binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II core promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to parathyroid hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to phorbol 13-acetate 12-myristate	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to prolactin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to zinc ion starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebral cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in conditioned taste aversion	IEP Inferred from Expression Pattern more info	PubMed
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in medium-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mononuclear cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in myoblast proliferation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
involved_in neural retina development	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to corticosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gravity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to muscle stretch	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle cell proliferation	IEP Inferred from Expression Pattern more info	PubMed
involved_in transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info
part_of transcription factor AP-1 complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein c-Fos

Names: FBJ murine osteosarcoma viral oncogene homolog; FBJ osteosarcoma oncogene; c-fos oncogene; proto-oncogene c-FOS; proto-oncogene cFOS; v-fos FBJ murine osteosarcoma viral oncogene homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022197.2 → NP_071533.1 protein c-Fos

See identical proteins and their annotated locations for NP_071533.1

Status: PROVISIONAL

Source sequence(s)

DQ089699

UniProtKB/Swiss-Prot

P12841, Q4FDN1

UniProtKB/TrEMBL

A6JE29

Related

ENSRNOP00000010712.2, ENSRNOT00000010712.5

Conserved Domains (1) summary

cd14721
Location:147 → 200

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain