Mtch2 mitochondrial carrier 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mtch2provided by RGD
Official Full Name: mitochondrial carrier 2provided by RGD
Primary source: RGD:1308080
See related: EnsemblRapid:ENSRNOG00000058658 AllianceGenome:RGD:1308080
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hspc032
Summary: This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]
Expression: Biased expression in Liver (RPKM 800.2), Heart (RPKM 701.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (97286388..97306028)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (76830549..76850189)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (79678141..79695356)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MTCH2 is related to testicular apoptosis, especially during meiotic prophase
Title: MTCH2 is differentially expressed in rat testis and mainly related to apoptosis of spermatocytes.
Identification and functional characterization of the human Mtch2 ortholog.
Title: Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142479 (e-PCR)
- UniSTS:231726

RH141100 (e-PCR)
- UniSTS:223097

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables membrane insertase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to radiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of protein localization to mitochondrial membrane involved in mitochondrial fission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic stem cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic stem cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hepatocyte apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lactate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial ATP synthesis coupled electron transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial fusion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of mitochondrial membrane permeability involved in apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: mitochondrial carrier homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106488.3 → NP_001099958.2 mitochondrial carrier homolog 2 isoform 1

See identical proteins and their annotated locations for NP_001099958.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (1).

Source sequence(s)

BC158687, BP503204, CB758525, DY315983, EV779017, FM085474, FM112089, FM132670

UniProtKB/TrEMBL

A0A0E3DAF7, A0A8I6ACP2, B0BN52

Related

ENSRNOP00000074292.2, ENSRNOT00000087604.3

Conserved Domains (1) summary

pfam00153
Location:128 → 192

Mito_carr; Mitochondrial carrier protein
NM_001317330.1 → NP_001304259.1 mitochondrial carrier homolog 2 isoform 1x

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), its location in the longer isoform is denoted by an 'X'.

Source sequence(s)

BC158687, BP503204, CB758525, DY315983, EV779017, FM085474, FM112089, FM132670

UniProtKB/TrEMBL

A0A8I6ACP2

Conserved Domains (1) summary

pfam00153
Location:128 → 192

Mito_carr; Mitochondrial carrier protein