Cklf chemokine-like factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cklfprovided by RGD
Official Full Name: chemokine-like factorprovided by RGD
Primary source: RGD:620708
See related: EnsemblRapid:ENSRNOG00000012752 AllianceGenome:RGD:620708
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cklf1
Summary: Predicted to enable chemokine activity. Involved in neutrophil chemotaxis. Predicted to be located in extracellular region. Predicted to be active in membrane. Orthologous to human CKLF (chemokine like factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 42.7), Testes (RPKM 29.9) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19p14

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (704528..712998, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (698097..706570, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (903609..914880, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuronal chemokine-like-factor 1 (CKLF1) up-regulation promotes M1 polarization of microglia in rat brain after stroke.
Title: Neuronal chemokine-like-factor 1 (CKLF1) up-regulation promotes M1 polarization of microglia in rat brain after stroke.
Inhibition of CKLF1 ameliorates hepatic ischemia-reperfusion injury via MAPK pathway.
Title: Inhibition of CKLF1 ameliorates hepatic ischemia-reperfusion injury via MAPK pathway.
CKLF1/CCR5 axis is involved in neutrophils migration of rats with transient cerebral ischemia.
Title: CKLF1/CCR5 axis is involved in neutrophils migration of rats with transient cerebral ischemia.
New treatment strategies to limit restenosis based on CKLF1 as a future target.
Title: CKLF1 aggravates neointimal hyperplasia by inhibiting apoptosis of vascular smooth muscle cells through PI3K/AKT/NF-κB signaling.
Chemokine-like factor 1 (CKLF1) is involved in blood-brain barrier disruption after reperfusion. Inhibition of CKLF1 protects against cerebral ischemia by maintaining BBB integrity, possibly via inhibiting the expression of aquaporin-4 and matrix metalloproteinase-9, and increasing the expression of tight junction protein.
Title: Inhibition of chemokine-like factor 1 improves blood-brain barrier dysfunction in rats following focal cerebral ischemia.
Results suggest that CKLF1 promotes the migration of rat primary cerebral cortical neurons by the induction of actin polymerization
Title: Chemokine-like factor 1 promotes the migration of rat primary cortical neurons by the induction of actin polymerization.
results suggest that CKLF1 is associated with neuronal apoptosis after cerebral ischemia and reperfusion
Title: Inhibition of chemokine-like factor 1 protects against focal cerebral ischemia through the promotion of energy metabolism and anti-apoptotic effect.
These data suggest that CKLF1 has a pivotal role in intimal hyperplasia by mediating VSMC migration. C19 was demonstrated to inhibit CKLF1-mediatated chemotaxis
Title: Antagonistic effect of C19 on migration of vascular smooth muscle cells and intimal hyperplasia induced by chemokine-like factor 1.
This study demonstrated that the expression of CKLF1 increases after focal cerebral ischemia in rat brain.
Title: Expression of chemokine-like factor 1 after focal cerebral ischemia in the rat.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chemokine activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in leukocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in lymphocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in neutrophil chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in secretion by cell	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chemokine-like factor

Names: chemokine-like factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.