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    Naa60 N(alpha)-acetyltransferase 60, NatF catalytic subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363545, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Naa60provided by RGD
    Official Full Name
    N(alpha)-acetyltransferase 60, NatF catalytic subunitprovided by RGD
    Primary source
    RGD:1308915
    See related
    EnsemblRapid:ENSRNOG00000007280 AllianceGenome:RGD:1308915
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    HAT4; NatF; Nat15; RGD1308915
    Summary
    Predicted to enable H4 histone acetyltransferase activity; peptide alpha-N-acetyltransferase activity; and protein homodimerization activity. Predicted to be involved in several processes, including chromosome segregation; nucleosome assembly; and protein acetylation. Predicted to be active in Golgi membrane. Orthologous to human NAA60 (N-alpha-acetyltransferase 60, NatF catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 117.2), Brain (RPKM 111.6) and 9 other tissues See more
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    Genomic context

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    See Naa60 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (12129026..12149053, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (11622554..11653078, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (11881635..11902139, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene SLX4 structure-specific endonuclease subunit Neighboring gene NLR family, CARD domain containing 3 Neighboring gene clusterin associated protein 1 Neighboring gene similar to human chromosome 16 open reading frame 90 Neighboring gene zinc finger protein 597 Neighboring gene zinc finger protein 174

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase. Chen JY, et al. Sci Rep, 2016 Aug 23. PMID 27550639, Free PMC Article
    2. Crystal Structure of the Golgi-Associated Human Nα-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation. Støve SI, et al. Structure, 2016 Jul 6. PMID 27320834, Free PMC Article
    3. HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase, acetylates free histone H4 and facilitates chromatin assembly. Yang X, et al. Mol Cell, 2011 Oct 7. PMID 21981917
    4. NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation. Van Damme P, et al. PLoS Genet, 2011 Jul. PMID 21750686, Free PMC Article
    5. An organellar nα-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity. Aksnes H, et al. Cell Rep, 2015 Mar 3. PMID 25732826

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124897

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H4 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H4 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-methionine acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 60
    Names
    GNAT acetyltransferase
    GNAT acetytransferase
    N-acetyltransferase 15 (GCN5-related, putative)
    N-alpha-acetyltransferase F
    histone acetyltransferase type B protein 4
    natF catalytic subunit
    NP_001014248.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014226.2 → NP_001014248.2  N-alpha-acetyltransferase 60

      See identical proteins and their annotated locations for NP_001014248.2

      Status: PROVISIONAL

      Source sequence(s)
      BC105304
      UniProtKB/Swiss-Prot
      Q3MHC1, Q7TMZ6
      Related
      ENSRNOP00000009936.3, ENSRNOT00000009936.8
      Conserved Domains (2) summary
      pfam00583
      Location:23 → 155
      Acetyltransf_1; Acetyltransferase (GNAT) family
      cl21457
      Location:139 → 203
      TIM; TIM-like beta/alpha barrel domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      12129026..12149053 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3MHC1.1 GenPept UniProtKB/Swiss-Prot:Q3MHC1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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