Fech ferrochelatase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fechprovided by RGD
Official Full Name: ferrochelataseprovided by RGD
Primary source: RGD:1307556
See related: EnsemblRapid:ENSRNOG00000018053 AllianceGenome:RGD:1307556
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables ferrochelatase activity. Involved in several processes, including cellular response to dexamethasone stimulus; response to lead ion; and response to platinum ion. Located in mitochondrion. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 360.4), Heart (RPKM 133.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (60215325..60248525, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (57945123..57978327, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (59941992..59975192, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ferrochelatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ferrochelatase activity	IDA Inferred from Direct Assay more info	PubMed
enables ferrochelatase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables iron-responsive element binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables tetrapyrrole binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of UV	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in heme A biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heme B biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heme O biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heme biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heme biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heme biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heme metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within porphyrin-containing compound biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protoporphyrinogen IX metabolic process	ISO Inferred from Sequence Orthology more info
involved_in protoporphyrinogen IX metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of eIF2 alpha phosphorylation by heme	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of hemoglobin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to arsenic-containing substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insecticide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to light stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to metal ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to methylmercury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to platinum ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within very-low-density lipoprotein particle assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ferrochelatase, mitochondrial

NP_001101904.1

EC 4.98.1.1

XP_006254912.1

EC 4.98.1.1

XP_038952906.1

EC 4.98.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108434.1 → NP_001101904.1 ferrochelatase, mitochondrial

See identical proteins and their annotated locations for NP_001101904.1

Status: PROVISIONAL

Source sequence(s)

CH473971

UniProtKB/TrEMBL

A0A8I5ZR41, A6IXN8, D3ZBM3

Related

ENSRNOP00000024328.4, ENSRNOT00000024328.6

Conserved Domains (3) summary

cd00419
Location:234 → 371

Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...

cd03411
Location:68 → 229

Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...

pfam00762
Location:68 → 388

Ferrochelatase; Ferrochelatase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

60215325..60248525 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096978.2 → XP_038952906.1 ferrochelatase, mitochondrial isoform X2

UniProtKB/TrEMBL

A0A8I5ZR41

Conserved Domains (1) summary

pfam00762
Location:1 → 317

Ferrochelatase
XM_006254850.5 → XP_006254912.1 ferrochelatase, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8I6GEM4

Related

ENSRNOP00000086143.2, ENSRNOT00000110759.2

Conserved Domains (3) summary

cd00419
Location:265 → 402

Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...

cd03411
Location:99 → 260

Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...

pfam00762
Location:99 → 419

Ferrochelatase; Ferrochelatase