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    Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252931, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Cyp3a18provided by RGD
    Official Full Name
    cytochrome P450, family 3, subfamily a, polypeptide 18provided by RGD
    Primary source
    RGD:628709
    See related
    EnsemblRapid:ENSRNOG00000000969 AllianceGenome:RGD:628709
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables testosterone 16-alpha-hydroxylase activity and testosterone 6-beta-hydroxylase activity. Predicted to be involved in oxidative demethylation and steroid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Orthologous to human CYP3A43 (cytochrome P450 family 3 subfamily A member 43). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 1612.2) See more
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    Genomic context

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    See Cyp3a18 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (13994312..14044185)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (8880509..8930382)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (10636294..10684273)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene histidine triad nucleotide binding protein 1 like 2 Neighboring gene uncharacterized LOC120095930 Neighboring gene ring finger protein 6 Neighboring gene heat shock protein 90 alpha family class A member 1, pseudogene 8 Neighboring gene cytochrome P450, family 3, subfamily a, polypeptide 73 Neighboring gene cytochrome P450, family 3, subfamily a, polypeptide 2 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a new rat P450 (CYP3A18) cDNA encoding P450(6)beta-2 catalyzing testosterone 6 beta- and 16 alpha-hydroxylations. Nagata K, et al. Pharmacogenetics, 1996 Feb. PMID 8845857
    2. A novel CYP3 gene from female rats. Strotkamp D, et al. Biochim Biophys Acta, 1995 Feb 21. PMID 7873612
    3. Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone. Williams PA, et al. Science, 2004 Jul 30. PMID 15256616
    4. Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme. Waxman DJ, et al. Arch Biochem Biophys, 1988 Jun. PMID 3259858
    5. An NH2-terminal truncated cytochrome P450 CYP3A4 showing catalytic activity is present in the cytoplasm of human liver cells. Jeon S, et al. Exp Mol Med, 2008 Apr 30. PMID 18446064, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aromatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables testosterone 16-alpha-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables testosterone 6-beta-hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables testosterone 6-beta-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in oxidative demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 3A18
    Names
    CYPIIIA18
    P450(6)beta-2
    cytochrome P450(6)beta-2
    cytochrome P450, 3a18
    NP_665725.2
    XP_038945036.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145782.2 → NP_665725.2  cytochrome P450 3A18

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q64581
      UniProtKB/TrEMBL
      A6K1D6, G3V635
      Related
      ENSRNOP00000001285.3, ENSRNOT00000001285.7
      Conserved Domains (1) summary
      cd20650
      Location:67 → 492
      CYP3A; cytochrome P450 family 3, subfamily A

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      13994312..14044185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089108.2 → XP_038945036.1  cytochrome P450 3A18 isoform X1

      Conserved Domains (1) summary
      cl41757
      Location:4 → 388
      cytochrome_P450; cytochrome P450 (CYP) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64581.1 GenPept UniProtKB/Swiss-Prot:Q64581

    Gene LinkOut

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