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    ZNF565 zinc finger protein 565 [ Homo sapiens (human) ]

    Gene ID: 147929, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF565provided by HGNC
    Official Full Name
    zinc finger protein 565provided by HGNC
    Primary source
    HGNC:HGNC:26726
    See related
    Ensembl:ENSG00000196357 MIM:614275; AllianceGenome:HGNC:26726
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 2.4), brain (RPKM 1.4) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF565 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36182060..36245928, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38727556..38794343, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36672962..36736830, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14519 Neighboring gene calpain small subunit 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36646245-36646976 Neighboring gene cytochrome c oxidase subunit 7A1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36678024-36678563 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36678564-36679102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36683570-36684070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36684071-36684571 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14521 Neighboring gene uncharacterized LOC107985304 Neighboring gene zinc finger protein 146 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36724474-36724976 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36724977-36725478 Neighboring gene MPRA-validated peak3458 silencer Neighboring gene MPRA-validated peak3459 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36735657-36736645 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:36736677-36736900 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:36737634-36738622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36748697-36749315 Neighboring gene uncharacterized LOC124904707 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36759575-36760152 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36762631-36763222 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36770206-36770810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36775291-36775913 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36786728-36787343 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36787344-36787958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36790483-36791084 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36791085-36791685 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36793635-36794244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36796811-36797424 Neighboring gene uncharacterized LOC100134317

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The human cytoplasmic dynein interactome reveals novel activators of motility. Redwine WB, et al. Elife, 2017 Jul 18. PMID 28718761, Free PMC Article
    2. Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease. Viard J, et al. Life Sci Alliance, 2022 Aug 1. PMID 35914814, Free PMC Article
    3. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36991

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 565

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042474.2 → NP_001035939.1  zinc finger protein 565 isoform 1

      See identical proteins and their annotated locations for NP_001035939.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1-4 encode the same isoform (1).
      Source sequence(s)
      AC008848, DA766324
      Consensus CDS
      CCDS12491.1
      UniProtKB/Swiss-Prot
      Q8N9K5
      Related
      ENSP00000376013.1, ENST00000392173.6
      Conserved Domains (3) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:193 → 498
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:309 → 329
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001366188.1 → NP_001353117.1  zinc finger protein 565 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (1).
      Source sequence(s)
      AC008848, AC012617
      Consensus CDS
      CCDS12491.1
      Related
      ENSP00000347234.5, ENST00000355114.9
      Conserved Domains (3) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:193 → 498
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:309 → 329
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001366189.1 → NP_001353118.1  zinc finger protein 565 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (1).
      Source sequence(s)
      AC008848, AC012617
      Consensus CDS
      CCDS12491.1
      Conserved Domains (3) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:193 → 498
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:309 → 329
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001366190.1 → NP_001353119.1  zinc finger protein 565 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks a portion of the 5' coding region compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC008848, AC012617
      Conserved Domains (2) summary
      COG5048
      Location:103 → 433
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:244 → 264
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_152477.5 → NP_689690.3  zinc finger protein 565 isoform 1

      See identical proteins and their annotated locations for NP_689690.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (1).
      Source sequence(s)
      AC008848, CB960081, DA473136
      Consensus CDS
      CCDS12491.1
      UniProtKB/Swiss-Prot
      Q8N9K5
      Related
      ENSP00000306869.5, ENST00000304116.10
      Conserved Domains (3) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:193 → 498
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:309 → 329
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      36182060..36245928 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026343.2 → XP_016881832.1  zinc finger protein 565 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:103 → 433
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:244 → 264
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_011526512.3 → XP_011524814.1  zinc finger protein 565 isoform X1

      See identical proteins and their annotated locations for XP_011524814.1

      UniProtKB/Swiss-Prot
      Q8N9K5
      Conserved Domains (3) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:193 → 498
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:309 → 329
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_011526514.3 → XP_011524816.1  zinc finger protein 565 isoform X1

      See identical proteins and their annotated locations for XP_011524816.1

      UniProtKB/Swiss-Prot
      Q8N9K5
      Conserved Domains (3) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:193 → 498
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:309 → 329
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      38727556..38794343 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319919.1 → XP_054175894.1  zinc finger protein 565 isoform X2

    2. XM_054319917.1 → XP_054175892.1  zinc finger protein 565 isoform X1

    3. XM_054319918.1 → XP_054175893.1  zinc finger protein 565 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N9K5.2 GenPept UniProtKB/Swiss-Prot:Q8N9K5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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