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    Stk10 serine/threonine kinase 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29398, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Stk10provided by RGD
    Official Full Name
    serine/threonine kinase 10provided by RGD
    Primary source
    RGD:3779
    See related
    EnsemblRapid:ENSRNOG00000004217 AllianceGenome:RGD:3779
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein homodimerization activity and protein serine/threonine kinase activity. Predicted to be involved in lymphocyte aggregation; protein autophosphorylation; and regulation of lymphocyte migration. Predicted to be located in plasma membrane. Orthologous to human STK10 (serine/threonine kinase 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 158.9), Thymus (RPKM 139.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q12
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (17622149..17716337)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (17117860..17212065)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (17420964..17521810)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ubiquitin domain containing 2 Neighboring gene EF-hand calcium binding domain 9 Neighboring gene uncharacterized LOC120095062 Neighboring gene uncharacterized LOC120095061 Neighboring gene F-box and WD repeat domain containing 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The identification of a novel cDNA preferentially expressed in the olfactory-limbic system of the adult rat. Schaar DG, et al. Brain Res, 1996 May 20. PMID 8793103
    2. Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes. Endo J, et al. FEBS Lett, 2000 Feb 25. PMID 10692593
    3. Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue. Walter SA, et al. J Biol Chem, 2003 May 16. PMID 12639966
    4. LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation. Belkina NV, et al. Proc Natl Acad Sci U S A, 2009 Mar 24. PMID 19255442, Free PMC Article
    5. Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. Pike AC, et al. EMBO J, 2008 Feb 20. PMID 18239682, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VIRMA promotes neuron apoptosis via inducing m6A methylation of STK10 in spinal cord injury animal models.
      Title: VIRMA promotes neuron apoptosis via inducing m6A methylation of STK10 in spinal cord injury animal models.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lymphocyte aggregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lymphocyte aggregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of lymphocyte migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of lymphocyte migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of lymphocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lymphocyte migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 10
    NP_062079.2
    XP_038941664.1
    XP_038941665.1
    XP_063124879.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019206.2 → NP_062079.2  serine/threonine-protein kinase 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      H9KVF6
      Related
      ENSRNOP00000044325.5, ENSRNOT00000047011.6
      Conserved Domains (3) summary
      cd06644
      Location:23 → 314
      STKc_STK10; Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK)
      smart00220
      Location:36 → 294
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam12474
      Location:768 → 908
      PKK; Polo kinase kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      17622149..17716337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085736.2 → XP_038941664.1  serine/threonine-protein kinase 10 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7Z9, H9KVF6
      Related
      ENSRNOP00000074413.2, ENSRNOT00000080404.3
      Conserved Domains (2) summary
      cd06644
      Location:23 → 314
      STKc_STK10; Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK)
      pfam12474
      Location:600 → 738
      PKK; Polo kinase kinase

    2. XM_063268809.1 → XP_063124879.1  serine/threonine-protein kinase 10 isoform X2

      UniProtKB/TrEMBL
      H9KVF6

    3. XM_039085737.2 → XP_038941665.1  serine/threonine-protein kinase 10 isoform X3

      UniProtKB/TrEMBL
      H9KVF6
      Conserved Domains (2) summary
      pfam12474
      Location:494 → 632
      PKK; Polo kinase kinase
      cl21453
      Location:2 → 208
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9PTG8.1 GenPept UniProtKB/Swiss-Prot:E9PTG8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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