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    Akap4 A-kinase anchoring protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79254, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Akap4provided by RGD
    Official Full Name
    A-kinase anchoring protein 4provided by RGD
    Primary source
    RGD:620828
    See related
    EnsemblRapid:ENSRNOG00000002921 AllianceGenome:RGD:620828
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein kinase A binding activity. Predicted to be involved in flagellated sperm motility and protein localization. Predicted to act upstream of or within establishment of protein localization; motile cilium assembly; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to be located in Z disc; perinuclear region of cytoplasm; and sperm flagellum. Predicted to be active in cytoplasm; sperm fibrous sheath; and sperm principal piece. Orthologous to human AKAP4 (A-kinase anchoring protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 819.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Akap4 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (18107256..18117549, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (15435391..15445684, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (16296027..16306078, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene chloride voltage-gated channel 5 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene U6 spliceosomal RNA Neighboring gene cyclin B3 Neighboring gene diacylglycerol kinase kappa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility. Miki K, et al. Dev Biol, 2002 Aug 15. PMID 12167408
    2. The major fibrous sheath polypeptide of mouse sperm: structural and functional similarities to the A-kinase anchoring proteins. Carrera A, et al. Dev Biol, 1994 Sep. PMID 8088444
    3. An X-linked gene encodes a major human sperm fibrous sheath protein, hAKAP82. Genomic organization, protein kinase A-RII binding, and distribution of the precursor in the sperm tail. Turner RM, et al. J Biol Chem, 1998 Nov 27. PMID 9822690
    4. Loss of SPEF2 function in mice results in spermatogenesis defects and primary ciliary dyskinesia. Sironen A, et al. Biol Reprod, 2011 Oct. PMID 21715716, Free PMC Article
    5. Changes in intracellular distribution and activity of protein phosphatase PP1gamma2 and its regulating proteins in spermatozoa lacking AKAP4. Huang Z, et al. Biol Reprod, 2005 Feb. PMID 15385410

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase A binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase A binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell surface receptor protein serine/threonine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of localization in cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm flagellum assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sperm flagellum assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in motile cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm end piece IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm end piece ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sperm fibrous sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm fibrous sheath IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm fibrous sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm midpiece IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sperm principal piece IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm principal piece IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    A-kinase anchor protein 4
    Names
    75 kDa fibrous sheath protein
    A kinase (PRKA) anchor protein 4
    AKAP-4
    PRKA4
    major sperm fibrous sheath protein
    protein kinase A-anchoring protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024402.1 → NP_077378.1  A-kinase anchor protein 4

      See identical proteins and their annotated locations for NP_077378.1

      Status: PROVISIONAL

      Source sequence(s)
      AF008114
      UniProtKB/Swiss-Prot
      O35774
      UniProtKB/TrEMBL
      A6KPB5, F1LMR8
      Related
      ENSRNOP00000003939.7, ENSRNOT00000003939.8
      Conserved Domains (1) summary
      smart00807
      Location:14 → 847
      AKAP_110; A-kinase anchor protein 110 kDa

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      18107256..18117549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100088.2 → XP_038956016.1  A-kinase anchor protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7I7
      Related
      ENSRNOP00000088271.1, ENSRNOT00000102856.2
      Conserved Domains (1) summary
      smart00807
      Location:5 → 838
      AKAP_110; A-kinase anchor protein 110 kDa
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35774.1 GenPept UniProtKB/Swiss-Prot:O35774

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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