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    Plin4 perilipin 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363331, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Plin4provided by RGD
    Official Full Name
    perilipin 4provided by RGD
    Primary source
    RGD:1590867
    See related
    EnsemblRapid:ENSRNOG00000047046 AllianceGenome:RGD:1590867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in cytosol; lipid droplet; and plasma membrane. Orthologous to human PLIN4 (perilipin 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 1545.7), Muscle (RPKM 1495.4) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plin4 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1016334..1025249, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (929168..938062, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (10963494..10972360)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene chromatin assembly factor 1 subunit A Neighboring gene UBX domain protein 6 Neighboring gene HDGF like 2 Neighboring gene perilipin 5 Neighboring gene leucine-rich alpha-2-glycoprotein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning of cell-specific secreted and surface proteins by subtractive antibody screening. Scherer PE, et al. Nat Biotechnol, 1998 Jun. PMID 9624692
    2. Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine. Moessinger C, et al. J Biol Chem, 2011 Jun 17. PMID 21498505, Free PMC Article
    3. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    perilipin 4; perilipin-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431328.1 → NP_001418257.1  perilipin 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    2. NM_001431329.1 → NP_001418258.1  perilipin 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    3. NM_001431330.1 → NP_001418259.1  perilipin 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    4. NM_001431331.1 → NP_001418260.1  perilipin 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      1016334..1025249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267952.1 → XP_063124022.1  perilipin-4 isoform X1

      UniProtKB/TrEMBL
      M0R7S5

    2. XM_063267953.1 → XP_063124023.1  perilipin-4 isoform X2

    3. XM_063267954.1 → XP_063124024.1  perilipin-4 isoform X3

      Related
      ENSRNOP00000100884.1, ENSRNOT00000172103.1

    4. XM_006244375.5 → XP_006244437.1  perilipin-4 isoform X3

      Conserved Domains (1) summary
      pfam03036
      Location:1151 → 1411
      Perilipin; Perilipin family

    5. XM_006244374.5 → XP_006244436.1  perilipin-4 isoform X2

      Related
      ENSRNOP00000065507.4, ENSRNOT00000075424.4
      Conserved Domains (1) summary
      pfam03036
      Location:1151 → 1435
      Perilipin; Perilipin family

    6. XM_006244372.5 → XP_006244434.1  perilipin-4 isoform X1

      See identical proteins and their annotated locations for XP_006244434.1

      UniProtKB/TrEMBL
      M0R7S5
      Conserved Domains (1) summary
      pfam03036
      Location:1151 → 1436
      Perilipin; Perilipin family

    7. XM_063267955.1 → XP_063124025.1  perilipin-4 isoform X4

      Related
      ENSRNOP00000107642.1, ENSRNOT00000152784.1

    8. XM_063267956.1 → XP_063124026.1  perilipin-4 isoform X5

    9. XM_063267957.1 → XP_063124027.1  perilipin-4 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials