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    Sgtb small glutamine rich tetratricopeptide repeat co-chaperone beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294708, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Sgtbprovided by RGD
    Official Full Name
    small glutamine rich tetratricopeptide repeat co-chaperone betaprovided by RGD
    Primary source
    RGD:727976
    See related
    EnsemblRapid:ENSRNOG00000011937 AllianceGenome:RGD:727976
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sgt2
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in posttranslational protein targeting to endoplasmic reticulum membrane and ubiquitin-dependent ERAD pathway. Predicted to be part of TRC complex. Predicted to be active in membrane. Orthologous to human SGTB (small glutamine rich tetratricopeptide repeat co-chaperone beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 301.6), Muscle (RPKM 65.8) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sgtb in Genome Data Viewer
    Location:
    2q13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (36966840..37003318)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (35233045..35269527)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (34185938..34222428)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100694 Neighboring gene neurolysin Neighboring gene trafficking protein particle complex subunit 13 Neighboring gene shieldin complex subunit 3 Neighboring gene tripartite motif-containing 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Up-regulation of SGTB is associated with neuronal apoptosis after neuroinflammation induced by lipopolysaccharide. Cao M, et al. J Mol Histol, 2013 Oct. PMID 23820636
    2. A brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string protein. Tobaben S, et al. J Biol Chem, 2003 Oct 3. PMID 12878599
    3. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Up-regulation of SGTB is associated with neuronal apoptosis in the rat neuroinflammation model.
      Title: Up-regulation of SGTB is associated with neuronal apoptosis after neuroinflammation induced by lipopolysaccharide.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Hsp70 protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in post-translational protein targeting to endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein heterooligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TRC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    small glutamine-rich tetratricopeptide repeat-containing protein beta
    Names
    beta-SGT
    small glutamine rich tetratricopeptide repeat containing beta
    small glutamine-rich protein with tetratricopeptide repeats 2
    small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181629.3 → NP_853660.1  small glutamine-rich tetratricopeptide repeat-containing protein beta

      See identical proteins and their annotated locations for NP_853660.1

      Status: PROVISIONAL

      Source sequence(s)
      AF368280
      UniProtKB/Swiss-Prot
      Q80W98
      UniProtKB/TrEMBL
      A0A8I6GA86, A6I5E8
      Conserved Domains (3) summary
      PLN03088
      Location:85 → 237
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:85 → 113
      TPR; TPR repeat [structural motif]
      pfam16546
      Location:5 → 64
      SGTA_dimer; Homodimerization domain of SGTA

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      36966840..37003318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231883.5 → XP_006231945.1  small glutamine-rich tetratricopeptide repeat-containing protein beta isoform X2

      UniProtKB/TrEMBL
      A0A8I6GA86
      Conserved Domains (4) summary
      sd00006
      Location:85 → 113
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:153 → 186
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:84 → 149
      TPR_11; TPR repeat
      pfam16546
      Location:7 → 64
      SGTA_dimer; Homodimerization domain of SGTA

    2. XM_063281504.1 → XP_063137574.1  small glutamine-rich tetratricopeptide repeat-containing protein beta isoform X2

      UniProtKB/TrEMBL
      A0A8I6GA86

    3. XM_006231882.5 → XP_006231944.1  small glutamine-rich tetratricopeptide repeat-containing protein beta isoform X1

      See identical proteins and their annotated locations for XP_006231944.1

      UniProtKB/Swiss-Prot
      Q80W98
      UniProtKB/TrEMBL
      A0A8I6GA86, A6I5E8
      Related
      ENSRNOP00000016129.3, ENSRNOT00000016129.7
      Conserved Domains (3) summary
      PLN03088
      Location:85 → 237
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:85 → 113
      TPR; TPR repeat [structural motif]
      pfam16546
      Location:5 → 64
      SGTA_dimer; Homodimerization domain of SGTA

    4. XM_063281505.1 → XP_063137575.1  small glutamine-rich tetratricopeptide repeat-containing protein beta isoform X3

      UniProtKB/TrEMBL
      A0A8I6GA86
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80W98.1 GenPept UniProtKB/Swiss-Prot:Q80W98

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