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    Ak5 adenylate kinase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365985, updated on 13-Jul-2024

    Summary

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    Official Symbol
    Ak5provided by RGD
    Official Full Name
    adenylate kinase 5provided by RGD
    Primary source
    RGD:1590818
    See related
    EnsemblRapid:ENSRNOG00000046947 AllianceGenome:RGD:1590818
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in nucleoside diphosphate phosphorylation and nucleoside triphosphate biosynthetic process. Predicted to be located in centriolar satellite. Predicted to be active in cytosol. Orthologous to human AK5 (adenylate kinase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 166.4), Kidney (RPKM 43.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ak5 in Genome Data Viewer
    Location:
    2q45
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (244057240..244241372, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (241397297..241581483, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (257671772..257864385, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100974 Neighboring gene mitoguardin 1 Neighboring gene ubiquitin specific peptidase 33 Neighboring gene zinc finger, ZZ-type containing 3 Neighboring gene uncharacterized LOC134485695 Neighboring gene uncharacterized LOC120100975 Neighboring gene NHP2-like protein 1 Neighboring gene uncharacterized LOC120100977 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class K

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein. Van Rompay AR, et al. Eur J Biochem, 1999 Apr. PMID 10215863
    2. The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. Amiri M, et al. Int J Biochem Cell Biol, 2013 May. PMID 23416111
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleoside diphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside monophosphate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adenylate kinase isoenzyme 5
    NP_001102421.1
    XP_017446496.1
    XP_063138379.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108951.1 → NP_001102421.1  adenylate kinase isoenzyme 5

      See identical proteins and their annotated locations for NP_001102421.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473952
      UniProtKB/TrEMBL
      A0A8I6GL77, A6HWM1, M0R7U1
      Related
      ENSRNOP00000065527.1, ENSRNOT00000072048.3
      Conserved Domains (2) summary
      TIGR01360
      Location:374 → 561
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
      cd01428
      Location:378 → 550
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      244057240..244241372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591007.3 → XP_017446496.1  adenylate kinase isoenzyme 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GL77

    2. XM_063282309.1 → XP_063138379.1  adenylate kinase isoenzyme 5 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GL77
    Nucleotide Protein Strain
    Heading Accession and Version

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