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    Ttf2 transcription termination factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295324, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Ttf2provided by RGD
    Official Full Name
    transcription termination factor 2provided by RGD
    Primary source
    RGD:1309145
    See related
    EnsemblRapid:ENSRNOG00000057761 AllianceGenome:RGD:1309145
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP-dependent activity, acting on DNA. Predicted to be located in cytosol. Orthologous to human TTF2 (transcription termination factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 96.4), Spleen (RPKM 79.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ttf2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (191054942..191086331, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (188366321..188397750, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (203317673..203350752, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene V-set domain containing T cell activation inhibitor 1 Neighboring gene uncharacterized LOC120100897 Neighboring gene tripartite motif-containing 45 Neighboring gene ribosomal protein L18A, pseudogene 3 Neighboring gene CD101 molecule Neighboring gene prostaglandin F2 receptor inhibitor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription termination factor 2
    Names
    transcription termination factor, RNA polymerase II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106454.3 → NP_001099924.2  transcription termination factor 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2K8A6, A6K3H0
      Related
      ENSRNOP00000075654.3, ENSRNOT00000084516.3
      Conserved Domains (5) summary
      cd00046
      Location:570 → 748
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      TIGR04420
      Location:166 → 307
      Sec_Non_Glob; Sec region non-globular protein
      pfam00176
      Location:553 → 913
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:970 → 1086
      Helicase_C; Helicase conserved C-terminal domain
      pfam06839
      Location:6 → 44
      zf-GRF; GRF zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      191054942..191086331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102063.2 → XP_038957991.1  transcription termination factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6T9, A6K3H0
      Related
      ENSRNOP00000074532.3, ENSRNOT00000090115.3
      Conserved Domains (2) summary
      COG0553
      Location:488 → 1075
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18072
      Location:485 → 735
      DEXHc_TTF2; DEAH-box helicase domain of TTF2

    RNA

    1. XR_005500265.2 RNA Sequence

    2. XR_005500266.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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