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    Eya2 EYA transcriptional coactivator and phosphatase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 156826, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Eya2provided by RGD
    Official Full Name
    EYA transcriptional coactivator and phosphatase 2provided by RGD
    Primary source
    RGD:620096
    See related
    EnsemblRapid:ENSRNOG00000019203 AllianceGenome:RGD:620096
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable magnesium ion binding activity and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including histone dephosphorylation; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; and positive regulation of DNA repair. Predicted to act upstream of or within apoptotic signaling pathway; protein dephosphorylation; and striated muscle tissue development. Predicted to be located in cytosol. Predicted to be active in nucleus. Orthologous to human EYA2 (EYA transcriptional coactivator and phosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 48.9), Thymus (RPKM 42.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3q42
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (174754772..174938035)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (154335598..154519006)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (162285275..162470642)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene engulfment and cell motility 2 Neighboring gene solute carrier family 2 member 10 Neighboring gene uncharacterized LOC120101927 Neighboring gene zinc finger, MYND-type containing 8 Neighboring gene uncharacterized LOC120101928

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcription coactivator Eya2 is a critical regulator of physiological hypertrophy. Lee SH, et al. J Mol Cell Cardiol, 2012 Mar. PMID 22197309
    2. Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent. Krishnan N, et al. J Biol Chem, 2009 Jun 12. PMID 19351884, Free PMC Article
    3. Misexpression of the eyes absent family triggers the apoptotic program. Clark SW, et al. J Biol Chem, 2002 Feb 1. PMID 11700312
    4. Eyes absent represents a class of protein tyrosine phosphatases. Rayapureddi JP, et al. Nature, 2003 Nov 20. PMID 14628052
    5. Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo. Grifone R, et al. Dev Biol, 2007 Feb 15. PMID 17098221

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitochondrial outer membrane permeabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within striated muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eyes absent homolog 2
    Names
    Drosophila-type eyes absent 2-like protein
    eyes absent 2 homolog
    NP_569111.2
    XP_038960091.1
    XP_038960092.1
    XP_038960093.1
    XP_063139094.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430138.1 → NP_001417067.1  eyes absent homolog 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      Q6UN47

    2. NM_001430139.1 → NP_001417068.1  eyes absent homolog 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      Q6UN47

    3. NM_130427.2 → NP_569111.2  eyes absent homolog 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      Q6UN47

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      174754772..174938035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283024.1 → XP_063139094.1  eyes absent homolog 2 isoform X4

    2. XM_039104164.2 → XP_038960092.1  eyes absent homolog 2 isoform X2

      Related
      ENSRNOP00000071977.3, ENSRNOT00000087530.3
      Conserved Domains (1) summary
      cd02601
      Location:260 → 531
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

    3. XM_039104163.2 → XP_038960091.1  eyes absent homolog 2 isoform X1

      Conserved Domains (1) summary
      cd02601
      Location:283 → 554
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains

    4. XM_039104165.2 → XP_038960093.1  eyes absent homolog 2 isoform X3

      UniProtKB/TrEMBL
      Q6UN47
      Conserved Domains (1) summary
      cd02601
      Location:201 → 472
      HAD_Eya; protein tyrosine phosphatase domain of the nuclear transcription factor of Eyes absent (Eya) and related phosphatase domains
    Nucleotide Protein Strain
    Heading Accession and Version

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