Sftpa1 surfactant protein A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sftpa1provided by RGD
Official Full Name: surfactant protein A1provided by RGD
Primary source: RGD:3665
See related: EnsemblRapid:ENSRNOG00000011438 AllianceGenome:RGD:3665
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PSAP; SP-A; PSP-A; Sftp1; Sftpa; Sftpl
Summary: Predicted to enable carbohydrate binding activity and metal ion binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to nitric oxide; and response to vitamin A. Located in extracellular space; multivesicular body; and rough endoplasmic reticulum. Biomarker of asthma; bacterial pneumonia; lung disease; newborn respiratory distress syndrome; and obesity. Human ortholog(s) of this gene implicated in lung disease (multiple) and respiratory syncytial virus infectious disease. Orthologous to several human genes including SFTPA1 (surfactant protein A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 7460.7) See more
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Genomic context

Location:: 16p14

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (17042264..17045770)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (17008180..17011686)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (18716019..18719404)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of the surfactant proteins SP-A and SP-B during postnatal alveolarization of the rat lung.
Title: The expression of the surfactant proteins SP-A and SP-B during postnatal alveolarization of the rat lung.
Surfactant Proteins A/D-CD14 on Alveolar Macrophages Is a Common Pathway Associated With Phagocytosis of Nanomaterials and Cytokine Production.
Title: Surfactant Proteins A/D-CD14 on Alveolar Macrophages Is a Common Pathway Associated With Phagocytosis of Nanomaterials and Cytokine Production.
Surfactant Protein A, a Novel Regulator for Smooth Muscle Phenotypic Modulation and Vascular Remodeling-Brief Report.
Title: Surfactant Protein A, a Novel Regulator for Smooth Muscle Phenotypic Modulation and Vascular Remodeling-Brief Report.
SP-A expression was up-regulated in the middle ear effusion of non-typeable Haemophilus influenza otitis media.
Title: Expression of surfactant Protein-A in the Haemophilus influenzae-induced otitis media in a rat model.
SPA binds dipalmitoyl-phosphatidylcholine, the major surfactant lipid component, but not phosphatidylinositol; SPD exhibits the opposite preference. Data suggest flexibility in a key surface loop supports distinctive lipid binding of SPA; quadruple mutant SPA (E171D/P175E/R197N/K203D) that introduces SPD-like loop-stabilizing Ca2+ binding site in carbohydrate recognition domain exhibits ligand-binding preferences of SPD.
Title: Differential Ligand Binding Specificities of the Pulmonary Collectins Are Determined by the Conformational Freedom of a Surface Loop.
Downregulation of SP-A expression caused due to silica is an important factor in the occurrence and development of silicosis.
Title: Expression of Peroxiredoxins and Pulmonary Surfactant Protein A Induced by Silica in Rat Lung Tissue.
Liraglutide activates the GLP1 receptor, increasing ACE2 expression, reversing right ventricle hypertrophy, and improving the production of SP-A and SP-B in the lungs of Type 1 Diabetes rats
Title: Activation of the GLP-1 Receptor by Liraglutide Increases ACE2 Expression, Reversing Right Ventricle Hypertrophy, and Improving the Production of SP-A and SP-B in the Lungs of Type 1 Diabetes Rats.
Mutations of rat surfactant protein A have distinct effects on its glycosylation, secretion, aggregation and degradation.
Title: Mutations of rat surfactant protein A have distinct effects on its glycosylation, secretion, aggregation and degradation.
Dual positive effects of leptin were found on protein expression and transcriptional activity of thyroid transcription factor-1
Title: Leptin promotes fetal lung maturity and upregulates SP-A expression in pulmonary alveoli type-II epithelial cells involving TTF-1 activation.
VIP can up-regulate the expression of SP-A in alveolar type II cells.
Title: [Influence of vasoactive intestinal peptide on expression of pulmonary surfactant associated protein A in lung explants].

Submit: New GeneRIF Correction See all GeneRIFs (38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sftpa1 (e-PCR), detects polymorphism
- UniSTS:516721

D16Mgh2 (e-PCR)
- UniSTS:119471

RH136969 (e-PCR)
- UniSTS:219058

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nitric oxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in opsonization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in respiratory gaseous exchange by respiratory system	IEA Inferred from Electronic Annotation more info
involved_in response to epidermal growth factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-6	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in multivesicular body	IBA Inferred from Biological aspect of Ancestor more info
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pulmonary surfactant-associated protein A

Names: Surfactant-associated protein 1 (pulmonary surfactant protein, SP-A); pulmonary surfactant-associated protein A-like; surfactant, pulmonary-associated protein A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270645.1 → NP_001257574.1 pulmonary surfactant-associated protein A isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

BC085353

UniProtKB/Swiss-Prot

P08427

Related

ENSRNOP00000039850.4, ENSRNOT00000047870.6

Conserved Domains (2) summary

cd03591
Location:146 → 258

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam01391
Location:37 → 108

Collagen; Collagen triple helix repeat (20 copies)
NM_001270647.1 → NP_001257576.1 pulmonary surfactant-associated protein A isoform 3 precursor

See identical proteins and their annotated locations for NP_001257576.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an additional segment in the 5' region and uses a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

BC085353, CK364490

UniProtKB/Swiss-Prot

P08427

Conserved Domains (2) summary

cd03591
Location:136 → 248

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam01391
Location:27 → 98

Collagen; Collagen triple helix repeat (20 copies)
NM_017329.2 → NP_059025.2 pulmonary surfactant-associated protein A isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal aa in the N-terminal region, compared to isoform 1.

Source sequence(s)

BC085353, M33201

UniProtKB/Swiss-Prot

P08427

Conserved Domains (2) summary

cd03591
Location:145 → 257

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam01391
Location:36 → 107

Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

17042264..17045770

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094199.1 → XP_038950127.1 pulmonary surfactant-associated protein A isoform X1

UniProtKB/Swiss-Prot

P08427

Conserved Domains (2) summary

cd03591
Location:136 → 248

CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)

pfam01391
Location:27 → 98

Collagen; Collagen triple helix repeat (20 copies)