Muc13 mucin 13, cell surface associated [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Muc13provided by RGD
Full Name: mucin 13, cell surface associatedprovided by RGD
Primary source: RGD:708547
See related: EnsemblRapid:ENSRNOG00000001794 AllianceGenome:RGD:708547
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ly64; MUC-13; Muc-123
Summary: Predicted to enable protein homodimerization activity. Predicted to be involved in maintenance of gastrointestinal epithelium. Located in apical plasma membrane. Biomarker of ischemia. Orthologous to human MUC13 (mucin 13, cell surface associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 4.1), Liver (RPKM 1.4) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (80462350..80489773, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (66957208..66980264, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (70185757..70223012, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mucin 15 is lost but mucin 13 remains in uterine luminal epithelial cells and the blastocyst at the time of implantation in the rat.
Title: Mucin 15 is lost but mucin 13 remains in uterine luminal epithelial cells and the blastocyst at the time of implantation in the rat.
These results indicate that mucin plays an important role in the preservation of the mucosal barrier and that ischemia but not digestive enzymes disturbs mucin integrity, while digestive enzymes actively mediate epithelial cell disruption.
Title: Breakdown of mucin as barrier to digestive enzymes in the ischemic rat small intestine.

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General gene information

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Markers

AI159736 (e-PCR)
- UniSTS:160562

UniSTS:224674 (e-PCR)
- UniSTS:224674

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in maintenance of gastrointestinal epithelium	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell periphery	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mucin-13

Names: lymphocyte antigen 64; mucin 13, epithelial transmembrane

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001421297.1 → NP_001408226.1 mucin-13

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

Related

ENSRNOP00000067923.3, ENSRNOT00000076114.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

80462350..80489773 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270271.1 → XP_063126341.1 mucin-13 isoform X1

UniProtKB/TrEMBL

A0A096MIY5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_139041.1: Suppressed sequence

Description

NM_139041.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.