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    Llgl2 LLGL scribble cell polarity complex component 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360661, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Llgl2provided by RGD
    Official Full Name
    LLGL scribble cell polarity complex component 2provided by RGD
    Primary source
    RGD:1560307
    See related
    EnsemblRapid:ENSRNOG00000004834 AllianceGenome:RGD:1560307
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560307
    Summary
    Predicted to enable GTPase activator activity; PDZ domain binding activity; and myosin II binding activity. Predicted to be involved in several processes, including cytoskeleton organization; leucine transport; and regulation of Notch signaling pathway. Predicted to act upstream of or within establishment or maintenance of polarity of embryonic epithelium; labyrinthine layer development; and post-embryonic development. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in cortical actin cytoskeleton and plasma membrane. Orthologous to human LLGL2 (LLGL scribble cell polarity complex component 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 109.5), Liver (RPKM 75.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Llgl2 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (101549911..101585466)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101050978..101086527)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (104367826..104403726)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene cask-interacting protein 2 Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene myosin XVB Neighboring gene RecQ like helicase 5 Neighboring gene small integral membrane protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LLGL2 rescues nutrient stress by promoting leucine uptake in ER(+) breast cancer. Saito Y, et al. Nature, 2019 May. PMID 30996345
    2. Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division. Yasumi M, et al. J Biol Chem, 2005 Feb 25. PMID 15632202
    3. Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Yamanaka T, et al. Curr Biol, 2003 Apr 29. PMID 12725730
    4. Mammalian Llgl2 is necessary for proper branching morphogenesis during placental development. Sripathy S, et al. Mol Cell Biol, 2011 Jul. PMID 21606200, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myosin II binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-leucine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within establishment or maintenance of polarity of embryonic epithelium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within labyrinthine layer blood vessel development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within placenta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of establishment or maintenance of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of establishment or maintenance of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LLGL scribble cell polarity complex component 2
    Names
    LLGL2, scribble cell polarity complex component
    lethal giant larvae homolog 2, scribble cell polarity complex component
    lethal(2) giant larvae protein homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127549.1 → NP_001121021.1  LLGL scribble cell polarity complex component 2

      See identical proteins and their annotated locations for NP_001121021.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166481
      UniProtKB/TrEMBL
      A0A0G2JU05, B2GV09
      Related
      ENSRNOP00000090333.1, ENSRNOT00000107003.2
      Conserved Domains (3) summary
      COG2319
      Location:36 → 267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:36 → 72
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271 → 371
      LLGL; LLGL2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      101549911..101585466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247728.5 → XP_006247790.1  LLGL scribble cell polarity complex component 2 isoform X5

      See identical proteins and their annotated locations for XP_006247790.1

      UniProtKB/TrEMBL
      A0A0G2JU05, F7F3E6
      Related
      ENSRNOP00000068912.3, ENSRNOT00000080714.3
      Conserved Domains (3) summary
      COG2319
      Location:36 → 267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:36 → 72
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271 → 371
      LLGL; LLGL2

    2. XM_006247729.5 → XP_006247791.1  LLGL scribble cell polarity complex component 2 isoform X5

      See identical proteins and their annotated locations for XP_006247791.1

      UniProtKB/TrEMBL
      A0A0G2JU05, F7F3E6
      Related
      ENSRNOP00000006519.4, ENSRNOT00000006519.6
      Conserved Domains (3) summary
      COG2319
      Location:36 → 267
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:36 → 72
      7WD40; WD40 repeat [structural motif]
      pfam08366
      Location:271 → 371
      LLGL; LLGL2

    3. XM_006247725.5 → XP_006247787.3  LLGL scribble cell polarity complex component 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y153
      Related
      ENSRNOP00000077420.1, ENSRNOT00000111761.2

    4. XM_039086428.2 → XP_038942356.2  LLGL scribble cell polarity complex component 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y153

    5. XM_039086429.2 → XP_038942357.2  LLGL scribble cell polarity complex component 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y153

    6. XM_006247724.5 → XP_006247786.3  LLGL scribble cell polarity complex component 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y153
    Nucleotide Protein Strain
    Heading Accession and Version

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