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    Ino80e INO80 complex subunit E [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293494, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Ino80eprovided by RGD
    Official Full Name
    INO80 complex subunit Eprovided by RGD
    Primary source
    RGD:1359572
    See related
    EnsemblRapid:ENSRNOG00000019960 AllianceGenome:RGD:1359572
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc95
    Summary
    Predicted to be involved in DNA recombination; DNA repair; and chromatin remodeling. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of Ino80 complex. Orthologous to human INO80E (INO80 complex subunit E). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 97.2), Kidney (RPKM 90.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ino80e in Genome Data Viewer
    Location:
    1q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190891315..190902902, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181461406..181472059, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198287489..198298076, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene TLC domain containing 3B Neighboring gene uncharacterized LOC134483857 Neighboring gene similar to human chromosome 16 open reading frame 92 Neighboring gene double C2 domain alpha Neighboring gene HIRA interacting protein 3 Neighboring gene TAO kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. Chen L, et al. J Biol Chem, 2011 Apr 1. PMID 21303910, Free PMC Article
    2. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21502417
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomere maintenance in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA strand elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Ino80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ino80 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Ino80 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    INO80 complex subunit E
    Names
    coiled-coil domain containing 95
    coiled-coil domain-containing protein 95

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013900.1 → NP_001013922.1  INO80 complex subunit E

      See identical proteins and their annotated locations for NP_001013922.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079045
      UniProtKB/Swiss-Prot
      Q6AYH2
      UniProtKB/TrEMBL
      A0A8I6G9J0, A6I9G3
      Related
      ENSRNOP00000027034.5, ENSRNOT00000027033.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      190891315..190902902 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286191.1 → XP_063142261.1  INO80 complex subunit E isoform X9

    2. XM_063286198.1 → XP_063142268.1  INO80 complex subunit E isoform X11

      UniProtKB/TrEMBL
      A6I9G9

    3. XM_063286185.1 → XP_063142255.1  INO80 complex subunit E isoform X8

    4. XM_063286151.1 → XP_063142221.1  INO80 complex subunit E isoform X1

      UniProtKB/Swiss-Prot
      Q6AYH2
      UniProtKB/TrEMBL
      A0A8I6G9J0, A6I9G3

    5. XM_063286152.1 → XP_063142222.1  INO80 complex subunit E isoform X1

      UniProtKB/Swiss-Prot
      Q6AYH2
      UniProtKB/TrEMBL
      A0A8I6G9J0, A6I9G3

    6. XM_063286175.1 → XP_063142245.1  INO80 complex subunit E isoform X6

      UniProtKB/TrEMBL
      A0A8I6G9J0

    7. XM_063286168.1 → XP_063142238.1  INO80 complex subunit E isoform X4

      UniProtKB/TrEMBL
      A0A8I6G9J0

    8. XM_006230243.4 → XP_006230305.1  INO80 complex subunit E isoform X2

      UniProtKB/TrEMBL
      A0A8I6G9J0
      Conserved Domains (1) summary
      pfam08537
      Location:12 → 97
      NBP1; Fungal Nap binding protein NBP1

    9. XM_006230245.4 → XP_006230307.1  INO80 complex subunit E isoform X5

      UniProtKB/TrEMBL
      A0A8I6G9J0, A0A8L2UKE2
      Related
      ENSRNOP00000083835.2, ENSRNOT00000107197.2
      Conserved Domains (1) summary
      pfam08537
      Location:12 → 65
      NBP1; Fungal Nap binding protein NBP1

    10. XM_006230244.4 → XP_006230306.1  INO80 complex subunit E isoform X3

      UniProtKB/TrEMBL
      A0A8I6G9J0

    11. XM_039107436.1 → XP_038963364.1  INO80 complex subunit E isoform X12

      UniProtKB/TrEMBL
      A0A8I6A0H5, A6I9G5, A6I9G8

    12. XM_039107432.1 → XP_038963360.1  INO80 complex subunit E isoform X12

      UniProtKB/TrEMBL
      A0A8I6A0H5, A6I9G5, A6I9G8

    13. XM_039107430.2 → XP_038963358.1  INO80 complex subunit E isoform X10

    14. XM_017588993.3 → XP_017444482.1  INO80 complex subunit E isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYH2.1 GenPept UniProtKB/Swiss-Prot:Q6AYH2

    Gene LinkOut

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