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    Esd esterase D [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290401, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Esdprovided by RGD
    Official Full Name
    esterase Dprovided by RGD
    Primary source
    RGD:1592114
    See related
    EnsemblRapid:ENSRNOG00000009512 AllianceGenome:RGD:1592114
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable S-formylglutathione hydrolase activity and identical protein binding activity. Predicted to be involved in formaldehyde catabolic process. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytosol. Orthologous to human ESD (esterase D). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 693.1), Liver (RPKM 593.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    15q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (56453082..56472582)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (50043634..50063134)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (56756848..56776348)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481990 Neighboring gene 5-hydroxytryptamine receptor 2A Neighboring gene leucine rich repeats and calponin homology domain containing 1 Neighboring gene uncharacterized LOC134482152 Neighboring gene uncharacterized LOC134482151

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The in vitro metabolism of a pyrethroid insecticide, permethrin, and its hydrolysis products in rats. Nakamura Y, et al. Toxicology, 2007 Jun 25. PMID 17451859
    2. Crystal structure of human esterase D: a potential genetic marker of retinoblastoma. Wu D, et al. FASEB J, 2009 May. PMID 19126594
    3. Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate. Sanghani SP, et al. Eur J Biochem, 2002 Sep. PMID 12230550
    4. Polymorphism of esterase 11 in Mus musculus, a further esterase locus on chromosome 8. Peters J, et al. Biochem Genet, 1977 Apr. PMID 869894
    5. Assignment of the gene for cytoplasmic glutamate-oxaloacetate transaminase to mouse chromosome 19 using chinese hamster x mouse somatic cell hybrids. Schäfer R, et al. Somatic Cell Genet, 1980 Nov. PMID 7444718

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables S-formylglutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-formylglutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in formaldehyde catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    S-formylglutathione hydrolase
    Names
    FGH
    esterase D/formylglutathione hydrolase
    NP_001099521.1
    NP_001257794.1
    NP_001257795.1
    XP_063130235.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106051.3 → NP_001099521.1  S-formylglutathione hydrolase isoform a

      See identical proteins and their annotated locations for NP_001099521.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      BC158790, FM108159
      UniProtKB/Swiss-Prot
      B0BNE5
      UniProtKB/TrEMBL
      A0A8L2UIQ9, A6HTR6
      Related
      ENSRNOP00000087309.2, ENSRNOT00000119329.2
      Conserved Domains (1) summary
      PLN02442
      Location:2 → 281
      PLN02442; S-formylglutathione hydrolase

    2. NM_001270865.1 → NP_001257794.1  S-formylglutathione hydrolase isoform a

      See identical proteins and their annotated locations for NP_001257794.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      BC158790, JAXUCZ010000015
      UniProtKB/Swiss-Prot
      B0BNE5
      UniProtKB/TrEMBL
      A0A8L2UIQ9, A6HTR6
      Related
      ENSRNOP00000068608.2, ENSRNOT00000078013.3
      Conserved Domains (1) summary
      PLN02442
      Location:2 → 281
      PLN02442; S-formylglutathione hydrolase

    3. NM_001270866.1 → NP_001257795.1  S-formylglutathione hydrolase isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      BC158790, FM108159
      UniProtKB/TrEMBL
      A0A8I6A7Q6
      Conserved Domains (2) summary
      COG0627
      Location:3 → 256
      FrmB; S-formylglutathione hydrolase FrmB [Defense mechanisms]
      cl21494
      Location:2 → 256
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      56453082..56472582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274165.1 → XP_063130235.1  S-formylglutathione hydrolase isoform X1

      UniProtKB/Swiss-Prot
      B0BNE5
      UniProtKB/TrEMBL
      A0A8L2UIQ9, A6HTR6
      Related
      ENSRNOP00000013324.6, ENSRNOT00000013324.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0BNE5.1 GenPept UniProtKB/Swiss-Prot:B0BNE5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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