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    lev-11 Tropomyosin;Tropomyosin isoforms a/b/d/f;Tropomyosin isoforms c/e [ Caenorhabditis elegans ]

    Gene ID: 173319, updated on 2-Nov-2024

    Summary

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    Official Symbol
    lev-11
    Official Full Name
    Tropomyosin;Tropomyosin isoforms a/b/d/f;Tropomyosin isoforms c/e
    Primary source
    WormBase:WBGene00002978
    Locus tag
    CELE_Y105E8B.1
    See related
    AllianceGenome:WB:WBGene00002978
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Is expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in blood platelet disease; congenital myopathy (multiple); distal arthrogryposis type 1A; and intrinsic cardiomyopathy (multiple). Orthologous to several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See lev-11 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    16
    Sequence:
    Chromosome: I; NC_003279.8 (14621169..14631094, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene DH domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Acyl-CoA dehydrogenase Neighboring gene ncRNA Neighboring gene Exocyst component Exo84 C-terminal domain-containing protein;PH domain-containing protein Neighboring gene Protein AF-9 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative splicing of a single exon causes a major impact on the affinity of Caenorhabditis elegans tropomyosin isoforms for actin filaments. Ono S, et al. Front Cell Dev Biol, 2023. PMID 37745299, Free PMC Article
    2. Genome structure, mapping and expression of the tropomyosin gene tmy-1 of Caenorhabditis elegans. Kagawa H, et al. J Mol Biol, 1995 Sep 1. PMID 7666414
    3. Alternative splicing of the Caenorhabditis elegans lev-11 tropomyosin gene is regulated in a tissue-specific manner. Watabe E, et al. Cytoskeleton (Hoboken), 2018 Oct. PMID 30155988, Free PMC Article
    4. Mutual dependence between tropomodulin and tropomyosin in the regulation of sarcomeric actin assembly in Caenorhabditis elegans striated muscle. Ono S, et al. Eur J Cell Biol, 2022 Apr. PMID 35306452, Free PMC Article
    5. The third and fourth tropomyosin isoforms of Caenorhabditis elegans are expressed in the pharynx and intestines and are essential for development and morphology. Anyanful A, et al. J Mol Biol, 2001 Oct 26. PMID 11676537

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results present models by which ELT-2, PHA-4, and CdxA orchestrate expression from the internal promoter of tmy-1/lev-11.
      Title: Transcription factors GATA/ELT-2 and forkhead/HNF-3/PHA-4 regulate the tropomyosin gene expression in the pharynx and intestine of Caenorhabditis elegans.
    2. Troponin C and tropomyosin are the actin-linked regulators for contraction of ovarian muscle in the C. elegans reproductive system.
      Title: Tropomyosin and troponin are required for ovarian contraction in the Caenorhabditis elegans reproductive system.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spicule insertion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in I band IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in striated muscle thin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tropomyosin;Tropomyosin isoforms a/b/d/f;Tropomyosin isoforms c/e
    NP_001021695.1
    • Confirmed by transcript evidence
    NP_001021697.1
    • Confirmed by transcript evidence
    NP_001300453.1
    • Confirmed by transcript evidence
    NP_001300454.1
    • Confirmed by transcript evidence
    NP_001300455.1
    • Confirmed by transcript evidence
    NP_001300456.1
    • Confirmed by transcript evidence
    NP_001300457.1
    • Confirmed by transcript evidence
    NP_001300458.1
    • Partially confirmed by transcript evidence
    NP_001300459.1
    • Partially confirmed by transcript evidence
    NP_001300460.1
    • Confirmed by transcript evidence
    NP_001300461.1
    • Partially confirmed by transcript evidence
    NP_001367007.1
    • Partially confirmed by transcript evidence
    NP_001367087.1
    • Confirmed by transcript evidence
    NP_001368154.1
    • Partially confirmed by transcript evidence
    NP_001368155.1
    • Partially confirmed by transcript evidence
    NP_001368156.1
    • Partially confirmed by transcript evidence
    NP_001370127.1
    • Confirmed by transcript evidence
    NP_001370969.1
    • Confirmed by transcript evidence
    NP_001379312.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14621169..14631094 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381266.2 → NP_001367087.1  Tropomyosin isoforms a/b/d/f [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam12718
      Location:7 → 112
      Tropomyosin_1; Tropomyosin like

    2. NM_001313528.5 → NP_001300457.1  Tropomyosin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AWP0
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin; Tropomyosin

    3. NM_001313525.5 → NP_001300454.1  Tropomyosin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ATR6
      Conserved Domains (2) summary
      pfam00261
      Location:20 → 254
      Tropomyosin; Tropomyosin
      pfam01496
      Location:112 → 180
      V_ATPase_I; V-type ATPase 116kDa subunit family

    4. NM_001026526.7 → NP_001021697.1  Tropomyosin isoforms c/e [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021697.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27249
      Conserved Domains (2) summary
      pfam00261
      Location:20 → 254
      Tropomyosin; Tropomyosin
      pfam01496
      Location:112 → 180
      V_ATPase_I; V-type ATPase 116kDa subunit family

    5. NM_001392977.1 → NP_001379312.1  Tropomyosin isoforms c/e [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27249, Q9GSR4
      Conserved Domains (1) summary
      pfam00261
      Location:20 → 254
      Tropomyosin

    6. NM_001381263.2 → NP_001367007.1  Tropomyosin isoforms a/b/d/f [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam00261
      Location:16 → 191
      Tropomyosin

    7. NM_001383761.2 → NP_001370127.1  Tropomyosin isoforms a/b/d/f [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    8. NM_001383762.2 → NP_001370969.1  Tropomyosin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1Q2U2F4
      Conserved Domains (1) summary
      pfam00261
      Location:20 → 254
      Tropomyosin

    9. NM_001313524.3 → NP_001300453.1  Tropomyosin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARB5
      Conserved Domains (1) summary
      pfam00261
      Location:20 → 254
      Tropomyosin; Tropomyosin

    10. NM_001026524.8 → NP_001021695.1  Tropomyosin isoforms a/b/d/f [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021695.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22865, Q22866, Q27284, Q7K6W7, Q95Q31
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin; Tropomyosin

    11. NM_001313531.4 → NP_001300460.1  Tropomyosin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AQT4
      Conserved Domains (3) summary
      COG4985
      Location:2 → 80
      COG4985; ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]
      pfam00261
      Location:48 → 282
      Tropomyosin; Tropomyosin
      pfam01496
      Location:140 → 208
      V_ATPase_I; V-type ATPase 116kDa subunit family

    12. NM_001313529.3 → NP_001300458.1  Tropomyosin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARC0
      Conserved Domains (3) summary
      COG4985
      Location:2 → 80
      COG4985; ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]
      pfam00261
      Location:48 → 282
      Tropomyosin; Tropomyosin
      pfam01496
      Location:140 → 225
      V_ATPase_I; V-type ATPase 116kDa subunit family

    13. NM_001313532.5 → NP_001300461.1  Tropomyosin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUC2
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin; Tropomyosin

    14. NM_001313530.3 → NP_001300459.1  Tropomyosin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ATS1
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin; Tropomyosin

    15. NM_001313526.3 → NP_001300455.1  Tropomyosin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AQS9
      Conserved Domains (1) summary
      pfam00261
      Location:16 → 191
      Tropomyosin; Tropomyosin

    16. NM_001313527.3 → NP_001300456.1  Tropomyosin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUC0
      Conserved Domains (1) summary
      pfam00261
      Location:1 → 153
      Tropomyosin; Tropomyosin

    17. NM_001381261.2 → NP_001368155.1  Tropomyosin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8FDX2
      Conserved Domains (1) summary
      pfam00261
      Location:48 → 282
      Tropomyosin

    18. NM_001381264.1 → NP_001368156.1  Tropomyosin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8ESC3
      Conserved Domains (1) summary
      pfam00261
      Location:16 → 191
      Tropomyosin

    19. NM_001381265.1 → NP_001368154.1  Tropomyosin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8ERM4
      Conserved Domains (1) summary
      pfam00261
      Location:1 → 153
      Tropomyosin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22866.1
    Q27249.1

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