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    sup-17 Disintegrin and metalloproteinase domain-containing protein 10 homolog [ Caenorhabditis elegans ]

    Gene ID: 172689, updated on 2-Nov-2024

    Summary

    Official Symbol
    sup-17
    Official Full Name
    Disintegrin and metalloproteinase domain-containing protein 10 homolog
    Primary source
    WormBase:WBGene00006324
    Locus tag
    CELE_DY3.7
    See related
    AllianceGenome:WB:WBGene00006324
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development. Located in cytoplasmic vesicle membrane and plasma membrane. Is expressed in several structures, including M lineage cell; germ line; intestinal cell; spermatheca; and vulva. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See sup-17 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    15
    Sequence:
    Chromosome: I; NC_003279.8 (8792965..8797288)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Malate dehydrogenase Neighboring gene tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)] Neighboring gene CID domain-containing protein

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metallopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Disintegrin and metalloproteinase domain-containing protein 10 homolog
    NP_492377.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8792965..8797288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059976.8NP_492377.1  Disintegrin and metalloproteinase domain-containing protein 10 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492377.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFD9
      Conserved Domains (4) summary
      smart00050
      Location:520611
      DISIN; Homologues of snake disintegrins
      cd04270
      Location:242513
      ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
      pfam01562
      Location:50142
      Pep_M12B_propep; Reprolysin family propeptide
      cl00232
      Location:805897
      Ribosomal_L19e; Ribosomal protein L19e. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an extended segment. ...