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    enu-3.1 ENhancer of Uncoordination [ Caenorhabditis elegans ]

    Gene ID: 176463, updated on 2-Nov-2024

    Summary

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    Official Symbol
    enu-3.1
    Official Full Name
    ENhancer of Uncoordination
    Primary source
    WormBase:WBGene00010362
    Locus tag
    CELE_H04D03.1
    See related
    AllianceGenome:WB:WBGene00010362
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in axon extension involved in axon guidance. Located in neuronal cell body. Is expressed in head; nervous system; and seam cell. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See enu-3.1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (10436276..10438142)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene U4/U6 small nuclear ribonucleoprotein Prp3 Neighboring gene SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog Neighboring gene ncRNA Neighboring gene MLX-interacting protein;Ovule protein Neighboring gene DUF1330 domain-containing protein;PHD-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ENU-3 protein family members function in the Wnt pathway parallel to UNC-6/Netrin to promote motor neuron axon outgrowth in C. elegans. Florica RO, et al. Dev Biol, 2017 Oct 1. PMID 28694018
    2. ENU-3 is a novel motor axon outgrowth and guidance protein in C. elegans. Yee CS, et al. Dev Biol, 2011 Apr 15. PMID 21295567
    3. ENU-3 functions in an UNC-6/netrin dependent pathway parallel to UNC-40/DCC/frazzled for outgrowth and guidance of the touch receptor neurons in C. elegans. Yee C, et al. Dev Dyn, 2014 Mar. PMID 24123761
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the ENU-3 family proteins function in a pathway parallel to the UNC-6/Netrin pathway for motor neuron axon outgrowth, most likely in the Wnt pathway.
      Title: The ENU-3 protein family members function in the Wnt pathway parallel to UNC-6/Netrin to promote motor neuron axon outgrowth in C. elegans.
    2. identified a novel mutant, enu-3 (enhancer of Unc), that enhances the motor neuron axon outgrowth defects observed in strains that lack either the UNC-5 receptor or its ligand UNC-6/Netrin
      Title: ENU-3 is a novel motor axon outgrowth and guidance protein in C. elegans.
    3. ENU-3 functions in an UNC-6/netrin dependent pathway parallel to UNC-40/DCC/frazzled for outgrowth and guidance of the touch receptor neurons in C. elegans.
      Title: ENU-3 functions in an UNC-6/netrin dependent pathway parallel to UNC-40/DCC/frazzled for outgrowth and guidance of the touch receptor neurons in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in axon extension IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon extension involved in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon extension involved in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ENhancer of Uncoordination
    NP_499302.1
    • Product from WormBase gene class enu;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10436276..10438142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066901.6 → NP_499302.1  ENhancer of Uncoordination [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499302.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45607
      Conserved Domains (1) summary
      pfam04795
      Location:149 → 202
      PAPA-1; PAPA-1-like conserved region
    Nucleotide Protein
    Heading Accession and Version

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