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    plc-1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1;Phosphoinositide phospholipase C [ Caenorhabditis elegans ]

    Gene ID: 181274, updated on 2-Nov-2024

    Summary

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    Official Symbol
    plc-1
    Official Full Name
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1;Phosphoinositide phospholipase C
    Primary source
    WormBase:WBGene00004036
    Locus tag
    CELE_F31B12.1
    See related
    AllianceGenome:WB:WBGene00004036
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GTPase inhibitor activity; phosphatidylinositol phospholipase C activity; and small GTPase binding activity. Involved in several processes, including 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process; defense response to Gram-positive bacterium; and positive regulation of protein import into nucleus. Is expressed in several structures, including excretory system; intestine; neurons; spermatheca; and vulva. Human ortholog(s) of this gene implicated in gastric adenocarcinoma; nephrotic syndrome; nephrotic syndrome type 2; and nephrotic syndrome type 3. Orthologous to human PLCE1 (phospholipase C epsilon 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See plc-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    69
    Sequence:
    Chromosome: X; NC_003284.9 (10794857..10838650, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Transthyretin-like family protein Neighboring gene SCP domain-containing protein Neighboring gene DUF19 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene tRNA-Glu Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Syndecan Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phospholipase Cepsilon regulates ovulation in Caenorhabditis elegans. Kariya K, et al. Dev Biol, 2004 Oct 1. PMID 15355798
    2. FRAP analysis of membrane-associated proteins: lateral diffusion and membrane-cytoplasmic exchange. Goehring NW, et al. Biophys J, 2010 Oct 20. PMID 20959084, Free PMC Article
    3. Concentration memory-dependent synaptic plasticity of a taste circuit regulates salt concentration chemotaxis in Caenorhabditis elegans. Kunitomo H, et al. Nat Commun, 2013. PMID 23887678
    4. FLN-1/filamin is required for maintenance of actin and exit of fertilized oocytes from the spermatheca in C. elegans. Kovacevic I, et al. Dev Biol, 2010 Nov 15. PMID 20707996, Free PMC Article
    5. HLH-29 regulates ovulation in C. elegans by targeting genes in the inositol triphosphate signaling pathway. White A, et al. Biol Open, 2012 Mar 15. PMID 23213416, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Using genetic analysis and a calcium-sensitive fluorescent protein, we show that FLN-1 functions with PLC-1 to regulate IP3 production, calcium release, and contraction of the spermatheca
      Title: Filamin and phospholipase C-ε are required for calcium signaling in the Caenorhabditis elegans spermatheca.
    2. Phospholipase Cepsilon (plc-1)regulates ovulation in Caenorhabditis elegans.
      Title: Phospholipase Cepsilon regulates ovulation in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in activation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1;Phosphoinositide phospholipase C
    NP_001024617.1
    • Confirmed by transcript evidence
    NP_001024619.1
    • Confirmed by transcript evidence
    NP_001123141.2
    • Partially confirmed by transcript evidence
    NP_001129926.1
    • Confirmed by transcript evidence
    NP_001129927.1
    • Confirmed by transcript evidence
    NP_001359720.1
    • Partially confirmed by transcript evidence
    NP_001360635.1
    • Partially confirmed by transcript evidence
    NP_001360636.1
    • Partially confirmed by transcript evidence
    NP_001360637.1
    • Partially confirmed by transcript evidence
    NP_001360638.1
    • Partially confirmed by transcript evidence
    NP_001360639.1
    • Partially confirmed by transcript evidence
    NP_509805.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      10794857..10838650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029448.6 → NP_001024619.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024619.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFI8
      Conserved Domains (7) summary
      cd00275
      Location:1408 → 1529
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08596
      Location:909 → 1373
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:840 → 1529
      PLN02952; phosphoinositide phospholipase C
      smart00147
      Location:62 → 333
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00314
      Location:1572 → 1664
      RA; Ras association (RalGDS/AF-6) domain
      pfam09279
      Location:842 → 903
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl00155
      Location:1740 → 1840
      UBQ; Ubiquitin-like proteins

    2. NM_001029446.3 → NP_001024617.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024617.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ED55, G5EEI0, G5EEJ6, G5EFI5, G5EFI8
      Conserved Domains (7) summary
      cd00275
      Location:1408 → 1529
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08596
      Location:909 → 1373
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:840 → 1529
      PLN02952; phosphoinositide phospholipase C
      smart00147
      Location:62 → 333
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00314
      Location:1572 → 1664
      RA; Ras association (RalGDS/AF-6) domain
      pfam09279
      Location:842 → 903
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl00155
      Location:1740 → 1855
      UBQ; Ubiquitin-like proteins

    3. NM_077404.6 → NP_509805.3  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509805.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFI8
      Conserved Domains (7) summary
      cd00275
      Location:1408 → 1529
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08596
      Location:909 → 1373
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:840 → 1529
      PLN02952; phosphoinositide phospholipase C
      smart00147
      Location:62 → 333
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00314
      Location:1572 → 1664
      RA; Ras association (RalGDS/AF-6) domain
      pfam09279
      Location:842 → 903
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl00155
      Location:1738 → 1838
      UBQ; Ubiquitin-like proteins

    4. NM_001373489.2 → NP_001360637.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IMY5
      Conserved Domains (9) summary
      cd08596
      Location:2528 → 2992
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:2459 → 3148
      PLN02952; phosphoinositide phospholipase C
      smart00147
      Location:1681 → 1952
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00295
      Location:1354 → 1531
      B41; Band 4.1 homologues
      sd00045
      Location:193 → 219
      ANK; ANK repeat [structural motif]
      cd16203
      Location:2334 → 2514
      EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
      cd01780
      Location:3354 → 3457
      RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
      pfam12796
      Location:193 → 328
      Ank_2; Ankyrin repeats (3 copies)
      cl28922
      Location:3188 → 3282
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    5. NM_001129669.4 → NP_001123141.2  Phosphoinositide phospholipase C [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IJW2
      Conserved Domains (9) summary
      cd08596
      Location:2535 → 2999
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:2466 → 3155
      PLN02952; phosphoinositide phospholipase C
      smart00147
      Location:1688 → 1959
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00295
      Location:1361 → 1538
      B41; Band 4.1 homologues
      sd00045
      Location:193 → 219
      ANK; ANK repeat [structural motif]
      cd16203
      Location:2341 → 2521
      EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
      cd01780
      Location:3361 → 3464
      RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
      pfam12796
      Location:193 → 328
      Ank_2; Ankyrin repeats (3 copies)
      cl28922
      Location:3195 → 3289
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    6. NM_001373491.2 → NP_001360639.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IK11
      Conserved Domains (9) summary
      cd08596
      Location:2538 → 3002
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:2469 → 3158
      PLN02952; phosphoinositide phospholipase C
      smart00147
      Location:1691 → 1962
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00295
      Location:1364 → 1541
      B41; Band 4.1 homologues
      sd00045
      Location:193 → 219
      ANK; ANK repeat [structural motif]
      cd16203
      Location:2344 → 2524
      EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
      cd01780
      Location:3364 → 3467
      RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
      pfam12796
      Location:193 → 328
      Ank_2; Ankyrin repeats (3 copies)
      cl28922
      Location:3198 → 3292
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    7. NM_001373492.2 → NP_001360635.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKD8
      Conserved Domains (9) summary
      cd08596
      Location:2545 → 3009
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:2476 → 3165
      PLN02952; phosphoinositide phospholipase C
      smart00147
      Location:1698 → 1969
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00295
      Location:1371 → 1548
      B41; Band 4.1 homologues
      sd00045
      Location:193 → 219
      ANK; ANK repeat [structural motif]
      cd16203
      Location:2351 → 2531
      EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
      cd01780
      Location:3371 → 3474
      RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
      pfam12796
      Location:193 → 328
      Ank_2; Ankyrin repeats (3 copies)
      cl28922
      Location:3205 → 3299
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    8. NM_001373493.2 → NP_001360636.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IN51
      Conserved Domains (9) summary
      cd08596
      Location:2585 → 3049
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:2516 → 3205
      PLN02952; phosphoinositide phospholipase C
      smart00147
      Location:1738 → 2009
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00295
      Location:1411 → 1588
      B41; Band 4.1 homologues
      sd00045
      Location:193 → 219
      ANK; ANK repeat [structural motif]
      cd16203
      Location:2391 → 2571
      EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
      cd01780
      Location:3411 → 3514
      RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
      pfam12796
      Location:193 → 328
      Ank_2; Ankyrin repeats (3 copies)
      cl28922
      Location:3245 → 3339
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    9. NM_001373494.2 → NP_001359720.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (9) summary
      cd08596
      Location:2592 → 3056
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:2523 → 3212
      PLN02952; phosphoinositide phospholipase C
      smart00147
      Location:1745 → 2016
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00295
      Location:1418 → 1595
      B41; Band 4.1 homologues
      sd00045
      Location:193 → 219
      ANK; ANK repeat [structural motif]
      cd16203
      Location:2398 → 2578
      EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
      cd01780
      Location:3418 → 3521
      RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
      pfam12796
      Location:193 → 328
      Ank_2; Ankyrin repeats (3 copies)
      cl28922
      Location:3252 → 3346
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    10. NM_001373495.2 → NP_001360638.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V6M3C0
      Conserved Domains (9) summary
      cd08596
      Location:2595 → 3059
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:2526 → 3215
      PLN02952; phosphoinositide phospholipase C
      smart00147
      Location:1748 → 2019
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00295
      Location:1421 → 1598
      B41; Band 4.1 homologues
      sd00045
      Location:193 → 219
      ANK; ANK repeat [structural motif]
      cd16203
      Location:2401 → 2581
      EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
      cd01780
      Location:3421 → 3524
      RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
      pfam12796
      Location:193 → 328
      Ank_2; Ankyrin repeats (3 copies)
      cl28922
      Location:3255 → 3349
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    11. NM_001136454.3 → NP_001129926.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129926.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EFI8
      Conserved Domains (7) summary
      cd00275
      Location:1418 → 1539
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08596
      Location:919 → 1383
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:850 → 1539
      PLN02952; phosphoinositide phospholipase C
      smart00147
      Location:62 → 333
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00314
      Location:1582 → 1674
      RA; Ras association (RalGDS/AF-6) domain
      pfam09279
      Location:852 → 913
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl00155
      Location:1748 → 1848
      UBQ; Ubiquitin-like proteins

    12. NM_001136455.4 → NP_001129927.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129927.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFG8
      Conserved Domains (7) summary
      cd00275
      Location:1426 → 1547
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08596
      Location:927 → 1391
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:858 → 1547
      PLN02952; phosphoinositide phospholipase C
      smart00147
      Location:80 → 351
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00314
      Location:1590 → 1682
      RA; Ras association (RalGDS/AF-6) domain
      pfam09279
      Location:860 → 921
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl00155
      Location:1756 → 1856
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EFI8.1

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