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    rsp-8 RNA-binding protein;RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176613, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rsp-8
    Official Full Name
    RNA-binding protein;RRM domain-containing protein
    Primary source
    WormBase:WBGene00004705
    Locus tag
    CELE_C18D11.4
    See related
    AllianceGenome:WB:WBGene00004705
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and positive regulation of mRNA splicing, via spliceosome. Predicted to be part of spliceosomal complex. Is expressed in several structures, including enteric muscle; hypodermis; nervous system; pharyngeal-intestinal valve; and reproductive system. Orthologous to human TRA2A (transformer 2 alpha homolog) and TRA2B (transformer 2 beta homolog). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See rsp-8 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (11826418..11830974)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ACB domain-containing protein Neighboring gene Fcf2 domain-containing protein Neighboring gene pre-microRNA mir-1832.1 Neighboring gene NOT2/NOT3/NOT5 C-terminal domain-containing protein;Not3 domain-containing protein Neighboring gene L-dopachrome isomerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of SR and SR-related genes in Caenorhabditis elegans. Longman D, et al. EMBO J, 2000 Apr 3. PMID 10747030, Free PMC Article
    2. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article
    3. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article
    4. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
    5. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein;RRM domain-containing protein
    NP_001255142.1
    • Confirmed by transcript evidence
    NP_001255143.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11826418..11830974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268213.4 → NP_001255142.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255142.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XTZ2
      Conserved Domains (1) summary
      cd12363
      Location:77 → 154
      RRM_TRA2; RNA recognition motif in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

    2. NM_001268214.3 → NP_001255143.1  RNA-binding protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255143.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3MU77
    Nucleotide Protein
    Heading Accession and Version

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