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    mboa-2 O-acyltransferase;diacylglycerol O-acyltransferase [ Caenorhabditis elegans ]

    Gene ID: 179540, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mboa-2
    Official Full Name
    O-acyltransferase;diacylglycerol O-acyltransferase
    Primary source
    WormBase:WBGene00010408
    Locus tag
    CELE_H19N07.4
    See related
    AllianceGenome:WB:WBGene00010408
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable diacylglycerol O-acyltransferase activity. Predicted to be involved in triglyceride biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in cardiomyopathy and congenital diarrhea 7 with exudative enteropathy. Orthologous to human DGAT1 (diacylglycerol O-acyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See mboa-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (11119813..11122493, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Eukaryotic peptide chain release factor GTP-binding subunit;Translation elongation factor EFTu/EF1A C-terminal domain-containing protein Neighboring gene Ubiquitin carboxyl-terminal hydrolase 7 Neighboring gene MRG domain-containing protein Neighboring gene ATP synthase subunit d, mitochondrial Neighboring gene Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuronal lipolysis participates in PUFA-mediated neural function and neurodegeneration. Yang L, et al. EMBO Rep, 2020 Nov 5. PMID 33034119, Free PMC Article
    2. CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. Piazzesi A, et al. EMBO Rep, 2022 May 4. PMID 35297148, Free PMC Article
    3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diacylglycerol O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinol O-fatty-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    O-acyltransferase;diacylglycerol O-acyltransferase
    NP_001256301.2
    • Confirmed by transcript evidence
    NP_001256302.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11119813..11122493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269372.3 → NP_001256301.2  O-acyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBH6, Q9NCE1
      Conserved Domains (1) summary
      cl00738
      Location:67 → 477
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    2. NM_001269373.3 → NP_001256302.1  diacylglycerol O-acyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256302.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F1LIN4
      Conserved Domains (1) summary
      cl00738
      Location:1 → 295
      MBOAT; MBOAT, membrane-bound O-acyltransferase family
    Nucleotide Protein
    Heading Accession and Version

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