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    mup-4 Transmembrane matrix receptor MUP-4 [ Caenorhabditis elegans ]

    Gene ID: 176060, updated on 12-Jun-2024

    Summary

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    Gene symbol
    mup-4
    Gene description
    Transmembrane matrix receptor MUP-4
    Locus tag
    CELE_K07D8.1
    See related
    AllianceGenome:WB:WBGene00003497
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in cell adhesion. Located in hemidesmosome. Part of hemidesmosome associated protein complex. Is expressed in body wall musculature; hypodermis; pharynx; and touch receptor neurons. Orthologous to human MATN2 (matrilin 2) and MATN4 (matrilin 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See mup-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    20
    Sequence:
    Chromosome: III; NC_003281.10 (7479680..7489105, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene putative fumarate hydratase, mitochondrial Neighboring gene tRNA-synt_2 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MUP-4 is a novel transmembrane protein with functions in epithelial cell adhesion in Caenorhabditis elegans. Hong L, et al. J Cell Biol, 2001 Jul 23. PMID 11470827, Free PMC Article
    2. The mup-4 locus in Caenorhabditis elegans is essential for hypodermal integrity, organismal morphogenesis and embryonic body wall muscle position. Gatewood BK, et al. Genetics, 1997 May. PMID 9136009, Free PMC Article
    3. Mutations affecting nerve attachment of Caenorhabditis elegans. Shioi G, et al. Genetics, 2001 Apr. PMID 11290717, Free PMC Article
    4. C. elegans ankyrin repeat protein VAB-19 is a component of epidermal attachment structures and is essential for epidermal morphogenesis. Ding M, et al. Development, 2003 Dec. PMID 14534136
    5. Lethal mutations defining 112 complementation groups in a 4.5 Mb sequenced region of Caenorhabditis elegans chromosome III. Stewart HI, et al. Mol Gen Genet, 1998 Nov. PMID 9862482

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in hemidesmosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in hemidesmosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of hemidesmosome associated protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transmembrane matrix receptor MUP-4
    NP_498645.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7479680..7489105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066244.7 → NP_498645.1  Transmembrane matrix receptor MUP-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498645.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21281, Q964N4
      Conserved Domains (7) summary
      smart00179
      Location:920 → 954
      EGF_CA; Calcium-binding EGF-like domain
      smart00200
      Location:1495 → 1619
      SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
      pfam06247
      Location:893 → 1082
      Plasmod_Pvs28; Plasmodium ookinete surface protein Pvs28
      pfam07645
      Location:1772 → 1810
      EGF_CA; Calcium-binding EGF domain
      pfam12947
      Location:823 → 851
      EGF_3; EGF domain
      cl00057
      Location:436 → 604
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl21504
      Location:873 → 902
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21281.4

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