myo-1 Myosin-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: myo-1
Official Full Name: Myosin-1
Primary source: WormBase:WBGene00002348
Locus tag: CELE_R06C7.10
See related: AllianceGenome:WB:WBGene00002348
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: A structural constituent of muscle. Involved in muscle contraction and nematode pharyngeal pumping. Located in striated muscle myosin thick filament. Is expressed in pharynx. Human ortholog(s) of this gene implicated in several diseases, including arthrogryposis multiplex congenita; cardiomyopathy (multiple); congenital heart disease (multiple); contractures, pterygia, and spondylocarpotarsal fusion syndrome (multiple); and muscle tissue disease (multiple). Orthologous to several human genes including MYH1 (myosin heavy chain 1); MYH13 (myosin heavy chain 13); and MYH15 (myosin heavy chain 15). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See myo-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 9

Sequence:: Chromosome: I; NC_003279.8 (7258946..7267057, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

During the first cytokinesis of the Caenorhabditis elegans embryo, the amount of ring components (myosin, anillin) and the constriction rate increase with parallel exponential kinetics.
Title: A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R06C7.10 (e-PCR)
- UniSTS:312065

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of muscle	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in myofibril	IEA Inferred from Electronic Annotation more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in myosin filament	IEA Inferred from Electronic Annotation more info
located_in sarcomere	IEA Inferred from Electronic Annotation more info
located_in striated muscle myosin thick filament	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Myosin-1

NP_492053.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7258946..7267057 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059652.7 → NP_492053.1 Myosin-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492053.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P02567, Q19674

Conserved Domains (6) summary

cd01377
Location:98 → 773

MYSc_class_II; class II myosins, motor domain

pfam00063
Location:86 → 773

Myosin_head; Myosin head (motor domain)

pfam01576
Location:854 → 1918

Myosin_tail_1; Myosin tail

pfam02736
Location:33 → 71

Myosin_N; Myosin N-terminal SH3-like domain

cl19842
Location:1074 → 1224

DUF2213; Uncharacterized protein conserved in bacteria (DUF2213)

cl21455
Location:863 → 1071

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases