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    fdps-1 Farnesyl pyrophosphate synthase [ Caenorhabditis elegans ]

    Gene ID: 173075, updated on 18-Sep-2024

    Summary

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    Official Symbol
    fdps-1
    Official Full Name
    Farnesyl pyrophosphate synthase
    Primary source
    WormBase:WBGene00011058
    Locus tag
    CELE_R06C1.2
    See related
    AllianceGenome:WB:WBGene00011058
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable dimethylallyltranstransferase activity and geranyltranstransferase activity. Predicted to be involved in farnesyl diphosphate biosynthetic process. Predicted to be active in cytoplasm. Is expressed in germ line. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human FDPS (farnesyl diphosphate synthase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See fdps-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (11917806..11923915, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene NEDD8-conjugating enzyme ubc-12 Neighboring gene Protein mago nashi homolog Neighboring gene Histone deacetylase Neighboring gene WH2 domain-containing protein;Wiskott-Aldrich syndrome protein family member Neighboring gene RRM domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables dimethylallyltranstransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables geranyltranstransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring alkyl or aryl (other than methyl) groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in farnesyl diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoprenoid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pheromone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Farnesyl pyrophosphate synthase
    NP_493027.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      11917806..11923915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060626.7 → NP_493027.1  Farnesyl pyrophosphate synthase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493027.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62336
      Conserved Domains (1) summary
      cd00685
      Location:44 → 268
      Trans_IPPS_HT; Trans-Isoprenyl Diphosphate Synthases, head-to-tail
    Nucleotide Protein
    Heading Accession and Version

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