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    dmd-4 Doublesex- and mab-3-related transcription factor dmd-4 [ Caenorhabditis elegans ]

    Gene ID: 181581, updated on 2-Nov-2024

    Summary

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    Official Symbol
    dmd-4
    Official Full Name
    Doublesex- and mab-3-related transcription factor dmd-4
    Primary source
    WormBase:WBGene00007776
    Locus tag
    CELE_C27C12.6
    See related
    AllianceGenome:WB:WBGene00007776
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ubiquitin binding activity. Involved in synapse pruning. Predicted to be active in nucleus. Is expressed in head; head mesodermal cell; hypodermis; and neurons. Orthologous to human DMRT3 (doublesex and mab-3 related transcription factor 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See dmd-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    5
    Sequence:
    Chromosome: X; NC_003284.9 (14857303..14861852, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene DEgenerin Like Neighboring gene E3 ubiquitin-protein ligase LIN-1 Neighboring gene UNC93-like protein MFSD11 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serine/threonine-protein kinase ATR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin-dependent regulation of a conserved DMRT protein controls sexually dimorphic synaptic connectivity and behavior. Bayer EA, et al. Elife, 2020 Oct 6. PMID 33021200, Free PMC Article
    2. Characterization of the Doublesex/MAB-3 transcription factor DMD-9 in Caenorhabditis elegans. Godini R, et al. G3 (Bethesda), 2023 Feb 9. PMID 36454093, Free PMC Article
    3. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
    4. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    5. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sex differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse pruning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Doublesex- and mab-3-related transcription factor dmd-4
    NP_510466.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14857303..14861852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078065.5 → NP_510466.1  Doublesex- and mab-3-related transcription factor dmd-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510466.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18248
      Conserved Domains (2) summary
      cd14370
      Location:142 → 181
      CUE_DMA; CUE-like DMA domain found in the DM domain gene family encodes putative transcription factors DMRTA1, DMRTA2 and DMRTA3
      pfam00751
      Location:18 → 64
      DM; DM DNA binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18248.2

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