cand-1 Cullin-associated NEDD8-dissociated protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cand-1
Official Full Name: Cullin-associated NEDD8-dissociated protein 1
Primary source: WormBase:WBGene00013606
Locus tag: CELE_Y102A5A.1
See related: AllianceGenome:WB:WBGene00013606
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in regulation of protein deneddylation. Located in nucleus. Is expressed widely. Used to study cancer. Orthologous to human CAND1 (cullin associated and neddylation dissociated 1) and CAND2 (cullin associated and neddylation dissociated 2 (putative)). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cand-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 12

Sequence:: Chromosome: V; NC_003283.11 (16802872..16814957)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caenorhabditis elegans CAND-1 is capable of binding to all of the cullins
Title: C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y102A5A.1 (e-PCR)
- UniSTS:312896

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in SCF complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF complex assembly	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein deneddylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cullin-associated NEDD8-dissociated protein 1

NP_507244.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

16802872..16814957

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074843.6 → NP_507244.1 Cullin-associated NEDD8-dissociated protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_507244.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ED41

Conserved Domains (3) summary

pfam08623
Location:1080 → 1244

TIP120; TATA-binding protein interacting (TIP20)

pfam13646
Location:987 → 1070

HEAT_2; HEAT repeats

sd00044
Location:1005 → 1031

HEAT; HEAT repeat [structural motif]