gsp-2 Serine/threonine-protein phosphatase PP1-beta [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gsp-2
Official Full Name: Serine/threonine-protein phosphatase PP1-beta
Primary source: WormBase:WBGene00001748
Locus tag: CELE_F56C9.1
See related: AllianceGenome:WB:WBGene00001748
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein serine/threonine phosphatase activity. Predicted to be involved in cell division; chromatin organization; and meiotic cell cycle. Located in chromosome; cytoplasm; and nuclear membrane. Is expressed in several structures, including anal depressor muscle; intestine; nervous system; oocyte; and reproductive system. Orthologous to several human genes including PPP1CA (protein phosphatase 1 catalytic subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gsp-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 7

Sequence:: Chromosome: III; NC_003281.10 (7336587..7338765)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PP1 phosphatases control PAR-2 localization and polarity establishment in C. elegans embryos.
Title: PP1 phosphatases control PAR-2 localization and polarity establishment in C. elegans embryos.
During nuclear assembly, MEL-28 recruits PP1c to the periphery of decondensed chromatin, where it directs formation of a functional nuclear compartment. Thus, a pool of phosphatase activity associated with a kinetochore-localized nucleoporin contributes to two key events that occur during M-phase exit in metazoans: kinetochore disassembly and nuclear reassembly.
Title: A Nucleoporin Docks Protein Phosphatase 1 to Direct Meiotic Chromosome Segregation and Nuclear Assembly.
Protein phosphatase 1 is a critical regulator of ZYG-1. When protein phosphatase 1 is down-regulated, ZYG-1 levels increase leading to centrosome amplification.
Title: Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication.
LAB-1 is required to target GSP-2 to early meiotic nuclei.
Title: LAB-1 targets PP1 and restricts Aurora B kinase upon entrance into meiosis to promote sister chromatid cohesion.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS3-11 (e-PCR)
- UniSTS:241947

F56C9.1 (e-PCR)
- UniSTS:311860

F08F8.3 (e-PCR)
- UniSTS:309604

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Serine/threonine-protein phosphatase PP1-beta

NP_001022616.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7336587..7338765

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027445.7 → NP_001022616.1 Serine/threonine-protein phosphatase PP1-beta [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022616.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P48727

Conserved Domains (2) summary

PTZ00480
Location:5 → 315

PTZ00480; serine/threonine-protein phosphatase; Provisional

cd07414
Location:7 → 297

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain