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    epg-9 Autophagy-related protein 101 [ Caenorhabditis elegans ]

    Gene ID: 177040, updated on 2-Nov-2024

    Summary

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    Official Symbol
    epg-9
    Official Full Name
    Autophagy-related protein 101
    Primary source
    WormBase:WBGene00022078
    Locus tag
    CELE_Y69A2AR.7
    See related
    AllianceGenome:WB:WBGene00022078
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein kinase binding activity. Involved in aggrephagy. Predicted to be part of Atg1/ULK1 kinase complex. Predicted to be active in phagophore assembly site. Is expressed in several structures, including body wall musculature; hypodermis; intestine; pharyngeal muscle cell; and tail. Orthologous to human ATG101 (autophagy related 101). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See epg-9 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (2601141..2607464)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Si:ch211-22i13.2 Neighboring gene V-SNARE coiled-coil homology domain-containing protein Neighboring gene K Homology domain-containing protein;KH domain-containing protein;Protein kinase domain-containing protein Neighboring gene PEST proteolytic signal-containing nuclear protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autophagy and beyond: Unraveling the complexity of UNC-51-like kinase 1 (ULK1) from biological functions to therapeutic implications. Zou L, et al. Acta Pharm Sin B, 2022 Oct. PMID 36213540, Free PMC Article
    2. The C. elegans ATG101 homolog EPG-9 directly interacts with EPG-1/Atg13 and is essential for autophagy. Liang Q, et al. Autophagy, 2012 Oct. PMID 22885670
    3. The active zone protein Clarinet regulates synaptic sorting of ATG-9 and presynaptic autophagy. Xuan Z, et al. PLoS Biol, 2023 Apr. PMID 37053235, Free PMC Article
    4. Autophagy of germ-granule components, PGL-1 and PGL-3, contributes to DNA damage-induced germ cell apoptosis in C. elegans. Min H, et al. PLoS Genet, 2019 May. PMID 31125345, Free PMC Article
    5. Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9. Yang S, et al. Neuron, 2022 Mar 2. PMID 35065714, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aggrephagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Atg1/ULK1 kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Autophagy-related protein 101
    NP_001023565.1
    • Confirmed by transcript evidence
    NP_741338.2
    • Confirmed by transcript evidence
    NP_741339.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2601141..2607464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171287.6 → NP_741338.2  Autophagy-related protein 101 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741338.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95XH2
      Conserved Domains (1) summary
      pfam07855
      Location:10 → 212
      DUF1649; Protein of unknown function (DUF1649)

    2. NM_171288.5 → NP_741339.1  Autophagy-related protein 101 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741339.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0S0
      Conserved Domains (1) summary
      pfam07855
      Location:2 → 166
      DUF1649; Protein of unknown function (DUF1649)

    3. NM_001028394.5 → NP_001023565.1  Autophagy-related protein 101 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023565.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86DD3
      Conserved Domains (1) summary
      pfam07855
      Location:1 → 139
      DUF1649; Protein of unknown function (DUF1649)
    Nucleotide Protein
    Heading Accession and Version

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