pkc-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pkc-1
Primary source: WormBase:WBGene00004032
Locus tag: CELE_F57F5.5
See related: AllianceGenome:WB:WBGene00004032
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein kinase C activity. Involved in several processes, including insulin-like growth factor receptor signaling pathway; neuropeptide signaling pathway; and regulated exocytosis. Located in neuron projection. Is expressed in ganglia; linker cell; and neurons. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to several human genes including PRKCE (protein kinase C epsilon). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: V

Exon count:: 15

Sequence:: Chromosome: V; NC_003283.11 (12014385..12032131, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic analysis indicates that lin-45 and pkc-1 act together to regulate nose touch response; these results functionally link two conserved signaling pathways in adult C. elegans neurons and define distinct roles for PKC genes in vivo.
Title: PKC-1 acts with the ERK MAPK signaling pathway to regulate Caenorhabditis elegans mechanosensory response.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F57F5.5 (e-PCR)
- UniSTS:311917

F10C2.3 (e-PCR)
- UniSTS:307451

F10C2.1 (e-PCR)
- UniSTS:322047

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	NAS Non-traceable Author Statement more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chemosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dense core granule exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of response to drug	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of positive chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynaptic dense core granule exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynaptic dense core granule exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to salt	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to salt	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of chemical stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory perception of chemical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory processing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cholinergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in cholinergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IMP Inferred from Mutant Phenotype more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein kinase C;Protein kinase C-like 1B

NP_001256394.1

Confirmed by transcript evidence

NP_001256395.1

Confirmed by transcript evidence

NP_001256396.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

12014385..12032131 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001269466.4 → NP_001256395.1 Protein kinase C-like 1B [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256395.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G3MU31, P34885, Q20953

Conserved Domains (4) summary

cd04014
Location:3 → 132

C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon

smart00220
Location:378 → 638

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05591
Location:382 → 702

STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon

pfam00130
Location:249 → 301

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001269465.2 → NP_001256394.1 Protein kinase C-like 1B [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256394.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34885

Conserved Domains (3) summary

smart00220
Location:291 → 551

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05591
Location:295 → 615

STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon

pfam00130
Location:162 → 214

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
NM_001269467.3 → NP_001256396.1 Protein kinase C [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256396.1

Status: REVIEWED

UniProtKB/TrEMBL

H9G2Y7

Conserved Domains (4) summary

cd04014
Location:59 → 188

C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon

smart00220
Location:434 → 694

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05591
Location:438 → 758

STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon

pfam00130
Location:305 → 357

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)