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    nhr-40 Nuclear hormone receptor family member nhr-40 [ Caenorhabditis elegans ]

    Gene ID: 180560, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nhr-40
    Official Full Name
    Nuclear hormone receptor family member nhr-40
    Primary source
    WormBase:WBGene00003630
    Locus tag
    CELE_T03G6.2
    See related
    AllianceGenome:WB:WBGene00003630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including P1; P10; P11; egg-laying apparatus; and somatic nervous system. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See nhr-40 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    13
    Sequence:
    Chromosome: X; NC_003284.9 (2594003..2606732)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene YitH/HolE acetyltransferase (GNAT) domain-containing protein Neighboring gene glycerophosphocholine cholinephosphodiesterase Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NHR-40, a Caenorhabditis elegans supplementary nuclear receptor, regulates embryonic and early larval development. Brozová E, et al. Mech Dev, 2006 Sep. PMID 16920335
    2. Conserved nuclear hormone receptors controlling a novel plastic trait target fast-evolving genes expressed in a single cell. Sieriebriennikov B, et al. PLoS Genet, 2020 Apr. PMID 32282814, Free PMC Article
    3. Feeding-structure morphogenesis in "rhabditid" and diplogastrid nematodes is not controlled by a conserved genetic module. Theska T, et al. Evol Dev, 2024 Mar. PMID 38356318
    4. Proteomic analysis uncovers a metabolic phenotype in C. elegans after nhr-40 reduction of function. Pohludka M, et al. Biochem Biophys Res Commun, 2008 Sep 12. PMID 18616929, Free PMC Article
    5. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NHR-40 provides a link between metabolism and muscle development.
      Title: Proteomic analysis uncovers a metabolic phenotype in C. elegans after nhr-40 reduction of function.
    2. The nhr-40 loss of function phenotype includes irregular development of body wall muscle cells and impaired movement and coordination resembling neuromuscular affection.
      Title: NHR-40, a Caenorhabditis elegans supplementary nuclear receptor, regulates embryonic and early larval development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nuclear hormone receptor family member nhr-40
    NP_001024873.1
    • Confirmed by transcript evidence
    NP_001362027.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2594003..2606732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029702.5 → NP_001024873.1  Nuclear hormone receptor family member nhr-40 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024873.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22127
      Conserved Domains (2) summary
      cd06960
      Location:15 → 90
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:230 → 405
      HOLI; Ligand binding domain of hormone receptors

    2. NM_001374979.2 → NP_001362027.1  Nuclear hormone receptor family member nhr-40 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22127, Q8MPY4, Q9GTH6
      Conserved Domains (2) summary
      cd06960
      Location:31 → 106
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
      smart00430
      Location:246 → 421
      HOLI; Ligand binding domain of hormone receptors
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22127.4

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