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    ptp-2 [ Caenorhabditis elegans ]

    Gene ID: 24104681, updated on 22-Aug-2024

    Summary

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    Official Symbol
    ptp-2
    Primary source
    WormBase:WBGene00004214
    Locus tag
    CELE_F59G1.5
    See related
    AllianceGenome:WB:WBGene00004214
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Involved in several processes, including nematode larval development; positive regulation of signal transduction; and positive regulation of vulval development. Located in cytoplasmic vesicle. Is expressed in body wall musculature; head ganglion; pharynx; spermatheca; and tail. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to several human genes including PTPN6 (protein tyrosine phosphatase non-receptor type 6). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (5918647..5921617)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Ceramide glucosyltransferase 3 Neighboring gene ncRNA Neighboring gene Frataxin, mitochondrial Neighboring gene Serine/threonine-protein kinase VRK1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MSP hormonal control of the oocyte MAP kinase cascade and reactive oxygen species signaling. Yang Y, et al. Dev Biol, 2010 Jun 1. PMID 20380830, Free PMC Article
    2. The frataxin-encoding operon of Caenorhabditis elegans shows complex structure and regulation. Vázquez-Manrique RP, et al. Genomics, 2007 Mar. PMID 17174523
    3. The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans. Hopper NA. Genetics, 2006 May. PMID 16547100, Free PMC Article
    4. trans-Fatty acids facilitate DNA damage-induced apoptosis through the mitochondrial JNK-Sab-ROS positive feedback loop. Hirata Y, et al. Sci Rep, 2020 Feb 17. PMID 32066809, Free PMC Article
    5. The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development. Gutch MJ, et al. Genes Dev, 1998 Feb 15. PMID 9472025, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell projection organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tyrosine-protein phosphatase non-receptor type ptp-2
    NP_001293512.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5918647..5921617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306583.2 → NP_001293512.1  Tyrosine-protein phosphatase non-receptor type ptp-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293512.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EC24
      Conserved Domains (4) summary
      cd10340
      Location:10 → 114
      SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
      smart00194
      Location:263 → 579
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00252
      Location:132 → 217
      SH2; Src homology 2 domains
      cd00047
      Location:294 → 578
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EC24.1

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