oaz-1 Ornithine decarboxylase antizyme [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: oaz-1
Official Full Name: Ornithine decarboxylase antizyme
Primary source: WormBase:WBGene00022748
Locus tag: CELE_ZK484.1
See related: AllianceGenome:WB:WBGene00022748
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ornithine decarboxylase inhibitor activity. Predicted to be involved in positive regulation of protein catabolic process. Predicted to be active in cytoplasm and nucleus. Is expressed in spermathecal-uterine valve cell. Human ortholog(s) of this gene implicated in coronary restenosis. Orthologous to several human genes including OAZ1 (ornithine decarboxylase antizyme 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See oaz-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (6093307..6094437)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Induction of Ornithine decarboxylase antizyme -frameshifting also occurs under stressful conditions, even in the absence of polyamine synthesis and independent of polyamine concentrations.
Title: Polyamine-independent Expression of Caenorhabditis elegans Antizyme.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK484.1 (e-PCR)
- UniSTS:316302

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ornithine decarboxylase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine decarboxylase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ornithine decarboxylase antizyme

NP_001367573.1

Confirmed by transcript evidence

NP_001367574.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6093307..6094437

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380459.2 → NP_001367574.1 Ornithine decarboxylase antizyme [Caenorhabditis elegans]

Status: REVIEWED
NM_001380458.1 → NP_001367573.1 Ornithine decarboxylase antizyme [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A8WIR2, O44900, Q9NHZ6

Conserved Domains (1) summary

pfam02100
Location:73 → 159

ODC_AZ; Ornithine decarboxylase antizyme